Cross Talk between Histone Deacetylase 4 and STAT6 in the Transcriptional Regulation of Arginase 1 during Mouse Dendritic Cell Differentiation (vol 35, pg 63, 2015)
文献类型：期刊论文
| 作者 | Yang, Quan1; Wei, Jianyang1; Zhong, Limei1; Shi, Maohua1; Zhou, Pan1; Wu, Kang1; Zhang, Hui1,3; Zhou, Jie1,3; Huang, Xi3; Zuo, Shengkai2 |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 37期号:17页码:UNSP e00289-17 |
| 关键词 | Metagenome Next-generation sequencing 16S rRNA Enterotype Genome-wide association study |
| ISSN号 | 0270-7306 |
| DOI | 10.1128/MCB.00289-17 |
| 文献子类 | Correction |
| 英文摘要 | Distinct enterotypes have been observed in the human gut but little is known about the genetic basis of the microbiome. Moreover, it is not clear how many genetic differences exist between enterotypes within or between populations. In this study, both the 16S rRNA gene and the metagenomes of the gut microbiota were sequenced from 48 Han Chinese, 48 Kazaks, and 96 Uyghurs, and taxonomies were assigned after de novo assembly. Single nucleotide polymorphisms were also identified by referring to data from the Human Microbiome Project. Systematic analysis of the gut communities in terms of their abundance and genetic composition was also performed, together with a genome-wide association study of the host genomes. The gut microbiota of 192 subjects was clearly classified into two enterotypes (Bacteroides and Prevotella). Interestingly, both enterotypes showed a clear genetic differentiation in terms of their functional catalogue of genes, especially for genes involved in amino acid and carbohydrate metabolism. In addition, several differentiated genera and genes were found among the three populations. Notably, one human variant (rs878394) was identified that showed significant association with the abundance of Prevotella, which is linked to LYPIAL1, a gene associated with body fat distribution, the waist-hip ratio and insulin sensitivity. Taken together, considerable differentiation was observed in gut microbes between enterotypes and among populations that was reflected in both the taxonomic composition and the genetic makeup of their functional genes, which could have been influenced by a variety of factors, such as diet and host genetic variation. (C) 2017 Elsevier GmbH. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000407626500011 |
| 出版者 | AMER SOC MICROBIOLOGY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/619]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med, Guangzhou, Guangdong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China, 3.Sun Yat Sen Univ, Chinese Minist Educ, Key Lab Trop Dis Control, Guangzhou, Guangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Quan,Wei, Jianyang,Zhong, Limei,et al. Cross Talk between Histone Deacetylase 4 and STAT6 in the Transcriptional Regulation of Arginase 1 during Mouse Dendritic Cell Differentiation (vol 35, pg 63, 2015)[J]. MOLECULAR AND CELLULAR BIOLOGY,2017,37(17):UNSP e00289-17. |
| APA | Yang, Quan.,Wei, Jianyang.,Zhong, Limei.,Shi, Maohua.,Zhou, Pan.,...&,.(2017).Cross Talk between Histone Deacetylase 4 and STAT6 in the Transcriptional Regulation of Arginase 1 during Mouse Dendritic Cell Differentiation (vol 35, pg 63, 2015).MOLECULAR AND CELLULAR BIOLOGY,37(17),UNSP e00289-17. |
| MLA | Yang, Quan,et al."Cross Talk between Histone Deacetylase 4 and STAT6 in the Transcriptional Regulation of Arginase 1 during Mouse Dendritic Cell Differentiation (vol 35, pg 63, 2015)".MOLECULAR AND CELLULAR BIOLOGY 37.17(2017):UNSP e00289-17. |
入库方式： OAI收割
来源：上海营养与健康研究所
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