H3K14me3 genomic distributions and its regulation by KDM4 family demethylases (vol 28, pg 1, 2018)
文献类型：期刊论文
| 作者 | Zhao, Bin2,3; Xu, Wenqi2,3; Rong, Bowen2,3; Ye, Xuanjia2,3; Dai, Ruofei2,3; Li, Wenjing2,3; Lan, Fei2,3; Chen, Guoyu4; Han, Jing-Dong J.4; Chen, Jiajia5,6 |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2019 |
| 卷号 | 29期号:1页码:90-90 |
| ISSN号 | 1001-0602 |
| 关键词 | thyroid metabolism |
| DOI | 10.1038/s41422-018-0095-6 |
| 文献子类 | Correction |
| 英文摘要 | Objective: Recent studies have shown that neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, plays an important role in the prevention of obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD). Considering that thyroid hormone (TH) has profound effects on whole-body energy metabolism, we speculate that circulating Nrg4 levels might be altered in patients with hyperthyroidism. Design and methods: A total of 129 hyperthyroid patients and 100 healthy subjects were recruited. Of them, 39 hyperthyroid patients received thionamide treatment for 3 months until euthyroidism. Serum Nrg4 levels were determined using the ELISA method. To further confirm the relationship between TH and Nrg4, C57BL/6 mice were treated with T-3 and quantitative real-time PCR was performed to detect Nrg4 gene expression. Results: Serum Nrg4 levels were significantly elevated in hyperthyroid patients as compared with normal controls (3.84 +/- 1.63 vs 2.21 +/- 1.04 ng/mL, P < 0.001). After achieving euthyroidism by thionamide treatment, serum Nrg4 levels dropped markedly from 3.57 +/- 1.26 to 1.94 +/- 0.72 ng/ml (P < 0.001). After adjustment for potential confounders, serum Nrg4 levels were independently associated with hyperthyroidism. The upregulation of Nrg4 expression in the livers and white adipose tissues by T-3 was further confirmed by animal and cell culture experiments. Conclusions: Serum Nrg4 levels were increased in patients with hyperthyroidism. The liver and white adipose tissue might be primary sources contributing to elevated serum Nrg4 concentrations. |
| 学科主题 | Cell Biology |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000454806600012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/622]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China; 2.Fudan Univ, Zhongshan Hosp, Liver Canc Inst,Key Lab Epigenet & Metab,Minist S, Key Lab Carcinogenesis & Canc Invas,Minist Educ, Shanghai 200032, Peoples R China; 3.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China; 4.Chinese Acad Sci, Key Lab Computat Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Collaborat Innovat Ctr Genet & Dev Biol,Max Planc, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 5.Fudan Univ, Basic Med Coll, Inst Biomed Sci, Shanghai 20032, Peoples R China; 6.Fudan Univ, Basic Med Coll, Dept Syst Biol Med, Shanghai 20032, Peoples R China; 7.Fudan Univ, Dept Neurosurg, Huashan Hosp, Shanghai 200040, Peoples R China; 8.Jilin Univ, Hosp 1, Ctr Infect & Immun, Dept Resp Med, Changchun 130001, Jilin, Peoples R China; 9.Harvard Med Sch, Boston Childrens Hosp, Newborn Med Div, Boston, MA 02115 USA; 10.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA, |
| 推荐引用方式 GB/T 7714 | Zhao, Bin,Xu, Wenqi,Rong, Bowen,et al. H3K14me3 genomic distributions and its regulation by KDM4 family demethylases (vol 28, pg 1, 2018)[J]. CELL RESEARCH,2019,29(1):90-90. |
| APA | Zhao, Bin.,Xu, Wenqi.,Rong, Bowen.,Ye, Xuanjia.,Dai, Ruofei.,...&,.(2019).H3K14me3 genomic distributions and its regulation by KDM4 family demethylases (vol 28, pg 1, 2018).CELL RESEARCH,29(1),90-90. |
| MLA | Zhao, Bin,et al."H3K14me3 genomic distributions and its regulation by KDM4 family demethylases (vol 28, pg 1, 2018)".CELL RESEARCH 29.1(2019):90-90. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。