The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice
文献类型：期刊论文
| 作者 | Green, Cara L.2; Mitchell, Sharon E.2; Derous, Davina2; Lusseau, David2; Douglas, Alex2; Speakman, John R.2,3; Soltow, Quinlyn A.1; Jones, Dean P.1; Wang, Yingchun3; Chen, Luonan4 |
| 刊名 | JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
 |
| 出版日期 | 2019 |
| 卷号 | 74期号:1页码:16-26 |
| 关键词 | Metabolomics Calorie restriction Aging Vitamin E Amino acids Bile acids |
| ISSN号 | 1079-5006 |
| DOI | 10.1093/gerona/gly058 |
| 文献子类 | Article |
| 英文摘要 | Calorie restriction (CR) remains the most robust intervention to extend life span and improve health span. Using a global mass spectrometrybased metabolomics approach, we identified metabolites that were significantly differentially expressed in the plasma of C57BL/6 mice, fed graded levels of calorie restriction (10% CR, 20% CR, 30% CR, and 40% CR) compared with mice fed ad libitum for 12 hours a day. The differential expression of metabolites increased with the severity of CR. Pathway analysis revealed that graded CR had an impact on vitamin E and vitamin B levels, branched chain amino acids, aromatic amino acids, and fatty acid pathways. The majority of amino acids correlated positively with fat-free mass and visceral fat mass, indicating a strong relationship with body composition and vitamin E metabolites correlated with stomach and colon size, which may allude to the beneficial effects of investing in gastrointestinal organs with CR. In addition, metabolites that showed a graded effect, such as the sphinganines, carnitines, and bile acids, match our previous study on liver, which suggests not only that CR remodels the metabolome in a way that promotes energy efficiency, but also that some changes are conserved across tissues. |
| 学科主题 | Geriatrics & Gerontology |
| WOS关键词 | SHORT-TERM CALORIE ; DIETARY RESTRICTION ; PROTEIN RESTRICTION ; METABOLITE PROFILES ; LIFE EXTENSION ; ADIPOSE-TISSUE ; E CONSUMPTION ; EXPRESSION ; DOPAMINE ; IMPACT |
| 语种 | 英语 |
| WOS记录号 | WOS:000462190200003 |
| 出版者 | OXFORD UNIV PRESS INC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/624]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Emory Univ, Dept Med, Clin Biomarkers Lab, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USA; 2.Univ Aberdeen, Inst Biol & Environm Sci, Zool Bldg,Tillydrone Ave, Aberdeen AB24 2TZ, Scotland; 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China; 4.Chinese Acad Sci, Innovat Ctr Cell Signaling Network, Key Lab Syst Biol, Inst Biochem & Cell Biol, Beijing, Peoples R China; 5.Chinese Acad Sci, Key Lab Computat Biol, Max Planck Partner Inst Computat Biol, Shanghai Inst Biol Sci, Beijing, Peoples R China; 6.Univ Washington, Dept Pathol, Seattle, WA 98195 USA; 7.Univ Washington, Dept Biol, Seattle, WA 98195 USA, |
| 推荐引用方式 GB/T 7714 | Green, Cara L.,Mitchell, Sharon E.,Derous, Davina,et al. The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2019,74(1):16-26. |
| APA | Green, Cara L..,Mitchell, Sharon E..,Derous, Davina.,Lusseau, David.,Douglas, Alex.,...&,.(2019).The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,74(1),16-26. |
| MLA | Green, Cara L.,et al."The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 74.1(2019):16-26. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。