dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers
文献类型：期刊论文
| 作者 | Yang, Zhen2; Teschendorff, Andrew E.2; Wu, Liangcai1; Wang, Anqiang1; Zhao, Haitao1; Tang, Wei4; Zhao, Yi5; Teschendorff, Andrew E.3; , |
| 刊名 | NUCLEIC ACIDS RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 45期号:D1页码:D812-D818 |
| ISSN号 | 0305-1048 |
| DOI | 10.1093/nar/gkw1079 |
| 文献子类 | Article |
| 英文摘要 | MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an important role in cancer development. Large amount of differentially expressed miRNAs have been identified in various cancers by using high-throughput methods. It is therefore quite important to make a comprehensive collection of these miRNAs and to decipher their roles in oncogenesis and tumor progression. In 2010, we presented the first release of dbDEMC, representing a database for collection of differentially expressed miRNAs in human cancers obtained from microarray data. Here we describe an update of the database. dbDEMC 2.0 documents 209 expression profiling data sets across 36 cancer types and 73 subtypes, and a total of 2224 differentially expressed miRNAs were identified. An easy-to-use web interface was constructed that allows users to make a quick search of the differentially expressed miRNAs in certain cancer types. In addition, a new function of 'meta-profiling' was added to view differential expression events according to user-defined miRNAs and cancer types. We expect this database to continue to serve as a valuable source for cancer investigation and potential clinical application related to miRNAs. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | MICRORNA EXPRESSION ; CIRCULATING MICRORNAS ; MULTIPLE CANCERS ; BIOMARKERS ; PROFILES ; DISEASE ; RNAS |
| 语种 | 英语 |
| WOS记录号 | WOS:000396575500113 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/625]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Med Sci & Peking Union Med Coll CAMS, Peking Union Med Coll Hosp, Dept Liver Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China; 2.CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 3.UCL, UCL Canc Inst, Statist Canc Gen, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England, 4.Tianjin Univ, Sch Biotechnol Engn, 135 Yaguan Rd, Tianjin, Peoples R China; 5.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Zhen,Teschendorff, Andrew E.,Wu, Liangcai,et al. dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers[J]. NUCLEIC ACIDS RESEARCH,2017,45(D1):D812-D818. |
| APA | Yang, Zhen.,Teschendorff, Andrew E..,Wu, Liangcai.,Wang, Anqiang.,Zhao, Haitao.,...&,.(2017).dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers.NUCLEIC ACIDS RESEARCH,45(D1),D812-D818. |
| MLA | Yang, Zhen,et al."dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers".NUCLEIC ACIDS RESEARCH 45.D1(2017):D812-D818. |
入库方式： OAI收割
来源：上海营养与健康研究所
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