Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults
文献类型：期刊论文
| 作者 | Lu, Ling1,2,3; Bennett, Derrick A.1,2; Millwood, Iona Y.1,2; Parish, Sarah1,2,4; Bragg, Fiona1,2; Holmes, Michael V.1,2,4; Hill, Michael1,2; Walters, Robin G.1,2; Chen, Zhengming1,2; Clarke, Robert1,2 |
| 刊名 | PLOS MEDICINE
 |
| 出版日期 | 2018 |
| 卷号 | 15期号:5页码:e1002566 |
| 关键词 | GWAS CYP3A5 exome tacrolimus FAM26F |
| ISSN号 | 1549-1676 |
| DOI | 10.1371/journal.pmed.1002566 |
| 文献子类 | Article |
| 英文摘要 | Background Observational studies have reported that higher plasma 25-hydroxyvitamin D (25[ OH] D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. The aim of this study was to test the relevance of 25(OH) D for type 2 diabetes using genetically instrumented differences in plasma 25(OH) D concentrations. Methods and findings Data were available on four 25(OH) D single nucleotide polymorphisms (SNPs; n = 82,464), plasma 25(OH) D concentrations (n = 13,565), and cases with diabetes (n = 5,565) in the China Kadoorie Biobank (CKB). The effects on risk of diabetes were assessed by a genetic score using two 25(OH) D synthesis SNPs (DHCR7-rs12785878 and CYP2R1-rs10741657), with and without the addition of SNPs affecting the transport (GC/DBP-rs2282679) and catabolism (CYP24A1-rs6013897) of 25(OH) D. The CKB results were combined in a meta-analysis of 10 studies for the 2 synthesis SNPs (n = 58,312 cases) and 7 studies for all 4 SNPs (n = 32,796 cases). Mean (SD) 25(OH) D concentration was 62 (20) nmol/l in CKB, and the per allele effects of genetic scores on 25(OH) D were 2.87 (SE 0.39) for the synthesis SNPs and 3.54 (SE 0.32) for all SNPs. A 25-nmol/l higher biochemically measured 25(OH) D was associated with a 9% (95% CI: 0%-18%) lower risk of diabetes in CKB. In a meta-analysis of all studies, a 25-nmol/l higher genetically instrumented 25(OH) D concentration was associated with a 14% (95% CI: 3%-23%) lower risk of diabetes (p = 0.01) using the 2 synthesis SNPs. An equivalent difference in 25(OH) D using a genetic score with 4 SNPs was not significantly associated with diabetes (odds ratio 8%, 95% CI: -1% to 16%, lower risk, p = 0.07), but had some evidence of pleiotropy. A limitation of the meta-analysis was the access only to study level rather than individual level data. Conclusions The concordant risks of diabetes for biochemically measured and genetically instrumented differences in 25(OH) D using synthesis SNPs provide evidence for a causal effect of higher 25(OH) D for prevention of diabetes. |
| 学科主题 | General & Internal Medicine |
| WOS关键词 | D-BINDING PROTEIN ; GENOME-WIDE ASSOCIATION ; PLASMA 25-HYDROXYVITAMIN D ; D SUPPLEMENTATION ; GENETIC-DETERMINANTS ; CONTROLLED-TRIAL ; PREVENTION ; CALCIUM ; METAANALYSIS ; COHORT |
| 语种 | 英语 |
| WOS记录号 | WOS:000434236000005 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/628]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England; 2.Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Lab Nutr & Metab, Shanghai, Peoples R China; 4.Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England; 5.Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England; 6.Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England; 7.Chinese Acad Med Sci, Beijing, Peoples R China; 8.Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark; 9.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark; 10.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Lu, Ling,Bennett, Derrick A.,Millwood, Iona Y.,et al. Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults[J]. PLOS MEDICINE,2018,15(5):e1002566. |
| APA | Lu, Ling.,Bennett, Derrick A..,Millwood, Iona Y..,Parish, Sarah.,Bragg, Fiona.,...&Li, Liming.(2018).Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults.PLOS MEDICINE,15(5),e1002566. |
| MLA | Lu, Ling,et al."Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults".PLOS MEDICINE 15.5(2018):e1002566. |
入库方式： OAI收割
来源：上海营养与健康研究所
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