Association between common carotid artery diameter and target organ damage in essential hypertension
文献类型：期刊论文
| 作者 | Yang, Yan2; Wang, Yan2; Xu, Jianzhong2; Gao, Pingjin2; Gao, Pingjin1; , |
| 刊名 | JOURNAL OF HYPERTENSION
 |
| 出版日期 | 2018 |
| 卷号 | 36期号:3页码:537-543 |
| 关键词 | carotid intima-media thickness common carotid artery diameter essential hypertension left ventricular mass index pulse wave velocity target organ damage urinary albumin/creatinine ratio |
| ISSN号 | 0263-6352 |
| DOI | 10.1097/HJH.0000000000001590 |
| 文献子类 | Article |
| 英文摘要 | Objectives: To investigate the relationship between common carotid artery diameter (CCA-D) and target organ damage (TOD) in essential hypertension. Methods and results: A total of 200 essential hypertensive patients were enrolled (mean age 62.5 +/- 9.5, men 59.0%) and were classified into two groups by the height-adjusted mean median of CCA-D: patients with CCA-D/height less than 3.905mm/m (n = 100, 50%) and patients with CCA-D/height more than 3.905mm/m (n = 100, 50%). Patients with CCA-D/height more than 3.905mm/m have higher left ventricular mass index (LVMI) (P < 0.001) and higher prevalence of left ventricular hypertrophy (LVH) (P < 0.001), higher mean common carotid intima-media thickness (P = 0.008) and higher prevalence of carotid artery sclerosis (P = 0.03), higher pulse wave velocity (PWV) (P < 0.001) and higher prevalence of increased arterial stiffness (P = 0.01), higher urinary albumin/creatinine ratio (P = 0.001) and higher prevalence of microalbuminuria (P = 0.02) and greater number of TODs (P < 0.001) compared with the patients with CCA-D/height less than 3.905 mm/m. CCA-D was significantly correlated with LVMI, PWV and logarithmically transformed urinary albumin/creatinine ratio (r = 0.299, P < 0.001; r = 0.212, P = 0.007; r = 0.224, P = 0.005, respectively) after adjusting for cardiovascular risk factors. Multivariable stepwise linear regression analysis showed that number of TODs as well as individual TOD, including LVMI, PWV and logarithmically transformed urinary albumin/creatinine ratio, were independently correlated to height-adjusted mean CCA-D (all P < 0.05). Conclusion: Height-adjusted mean CCA-D was an independent risk factor for individual TOD, including LVMI, PWV and urinary albumin/creatinine ratio, as well as overall number of TODs in essential hypertension. |
| 学科主题 | Cardiovascular System & Cardiology |
| WOS关键词 | INTIMA-MEDIA THICKNESS ; URINARY ALBUMIN EXCRETION ; BLOOD-PRESSURE ; ENDOTHELIAL DYSFUNCTION ; ATHEROSCLEROSIS RISK ; WALL STIFFNESS ; HEART-DISEASE ; ENLARGEMENT ; MICROALBUMINURIA ; COMMUNITIES |
| 语种 | 英语 |
| WOS记录号 | WOS:000429317500013 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/630]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Vasc Biol, Shanghai, Peoples R China, 2.Shanghai Jiao Tong Univ, Dept Hypertens, State Key Lab Med Genom, Shanghai Key Lab Vasc Biol,Ruijin Hosp,Shanghai I, 197,Ruijin 2nd Rd, Shanghai 200025, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Yan,Wang, Yan,Xu, Jianzhong,et al. Association between common carotid artery diameter and target organ damage in essential hypertension[J]. JOURNAL OF HYPERTENSION,2018,36(3):537-543. |
| APA | Yang, Yan,Wang, Yan,Xu, Jianzhong,Gao, Pingjin,Gao, Pingjin,&,.(2018).Association between common carotid artery diameter and target organ damage in essential hypertension.JOURNAL OF HYPERTENSION,36(3),537-543. |
| MLA | Yang, Yan,et al."Association between common carotid artery diameter and target organ damage in essential hypertension".JOURNAL OF HYPERTENSION 36.3(2018):537-543. |
入库方式： OAI收割
来源：上海营养与健康研究所
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