A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study
文献类型：期刊论文
| 作者 | Li, Peiqin4; Zhao, Jing4; Li, Xiang4; Li, Hui4; Han, Yuxuan4; Gao, Ying4; Kothapalli, Kumar S. D.5,6; Brenna, J. Thomas5,6; Mi, Shengquan7; Zhao, Wenhua8 |
| 刊名 | AMERICAN JOURNAL OF CLINICAL NUTRITION
 |
| 出版日期 | 2018 |
| 卷号 | 107期号:6页码:867-875 |
| 关键词 | dyslipidemia gene polymorphism fatty acid desaturases insertion-deletion long-chain polyunsaturated fatty acids |
| ISSN号 | 0002-9165 |
| DOI | 10.1093/ajcn/nqy063 |
| 文献子类 | Article |
| 英文摘要 | Background: Arachidomc acid (AA) is the major polyunsaturated fatty acid (PUFA) substrate for potent eicosanoid signaling to modulate inflammation and thrombosis and is controlled in part by tissue abundance. Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-6) AA and n-3 eicosapentaenoic acid (EPA). The rs66698963 polymorphism, a 22-base pair (bp) insertion-deletion 137 bp downstream of a sterol regulatory element in FADS2 intron 1, mediates expression of FADS1 in vitro, as well as exerting positive selection in several human populations. The associations between the polymorphism rs66698963 and plasma PUFAs as well as disease phenotypes are unclear. Objective: This study aimed to evaluate the relation between rs66698963 genotypes and plasma PUFA concentrations and blood lipid profiles. Design: Plasma fatty acids were measured from a single sample obtained at baseline in 1504 healthy Chinese adults aged between 35 and 59 y with the use of gas chromatography. Blood lipids were measured at baseline and a second time at the 18-mo follow-up. The rs66698963 genotype was determined by using agarose gel electrophoresis. Linear regression and logistic regression analyses were performed to assess the association between genotype and plasma PUFAs and blood lipids. Results: A shift from the precursors linoleic acid and a-linolemc acid to produce AA and EPA, respectively, was observed, consistent with FADS 1 activity increasing in the order of genotypes D/D to I/D to I/I. For FI compared with D/D carriers, plasma concentrations of n-6 AA and the ratio of AA to n-3 EPA plus docosahexaenoic acid (DHA) were 57% and 32% higher, respectively. Carriers of the deletion (D) allele of rs66698963 tended to have higher triglycerides (beta= 0.008; SE: 0.009; P = 0.05) and lower HDL cholesterol (beta = -0.008; SE: 0.004; P = 0.02) than carriers of the insertion (I) allele. Conclusions: The rs66698963 genotype is significantly associated with AA concentrations and AA to EPA+DHA ratio, reflecting basal risk of inflammatory and related chronic disease phenotypes, and is correlated with the risk of dyslipidemia. This trial was registered at chictr.org.cn as ChiCTR-EOC-17012759. Am J Clin Nutr 2018;107:867-875. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | POLYUNSATURATED FATTY-ACIDS ; CORONARY-ARTERY-DISEASE ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; ASSOCIATION ; PLASMA ; DIETARY ; RISK ; INFLAMMATION ; SUPPLEMENTATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000435459400005 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/634]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA, 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China; 3.Fudan Univ, Sch Life Sci, Inst Biostat, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China; 5.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA; 6.Univ Texas Austin, Dell Med Sch, Dell Pediat Res Inst, Austin, TX 78712 USA; 7.Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China; 8.Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Peiqin,Zhao, Jing,Li, Xiang,et al. A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2018,107(6):867-875. |
| APA | Li, Peiqin.,Zhao, Jing.,Li, Xiang.,Li, Hui.,Han, Yuxuan.,...&,.(2018).A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study.AMERICAN JOURNAL OF CLINICAL NUTRITION,107(6),867-875. |
| MLA | Li, Peiqin,et al."A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study".AMERICAN JOURNAL OF CLINICAL NUTRITION 107.6(2018):867-875. |
入库方式： OAI收割
来源：上海营养与健康研究所
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