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Associations of Plasma Amino Acid and Acylcarnitine Profiles with Incident Reduced Glomerular Filtration Rate

文献类型：期刊论文

作者Wang, Feijie2; Sun, Liang2; Sun, Qi2; Liang,Liming2; Gao, Xianfu2; Li, Li, Rongxia2; Pan, An2; Li, Huaixing2; Deng, YYueyi2; Hu, Frank B.2
刊名CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
出版日期2018
卷号13期号:4页码:560-568
关键词Adult Incidence Metabolomics risk factors acylcarnitine Cysteine Metabolome Amino Acids glomerular filtration rate Principal Component Analysis Follow-Up Studies Genetic Background Carnitine Chromatography Liquid Renal Insufficiency Chronic Mass Spectrometry Biomarkers Environmental Exposure Humans
ISSN号1555-9041
DOI10.2215/CJN.07650717
文献子类Article
英文摘要Background and objectives Metabolomics is instrumental in identifying novel biomarkers of kidney function to aid in the prevention and management of CKD. However, data linking the metabolome to incident eGFR are sparse, particularly in Asian populations with different genetic backgrounds and environmental exposures. Therefore, we aimed to investigate the associations of amino acid and acylcarnitine profiles with change in eGFR in a Chinese cohort. Design, setting, participants, & measurements This study included 1765 community-living Chinese adults aged 50-70 years with baseline eGFR >= 60ml/min per 1.73 m(2). At baseline, 22 amino acids and 34 acylcarnitines in plasma were quantified by gas or liquid chromatography coupled with mass spectrometry. Annual rate of change in eGFR was calculated, and incident eGFR decline was defined as eGFR<60 ml/min per 1.73 m(2) by the end of 6 years of follow-up. Results The mean (SD) unadjusted annual change in eGFR was 2.22.0 ml/min per 1.73 m(2) and the incidence of reduced eGFR was 16%. After Bonferroni correction, 13 of 56 metabolites were significantly associated with annual eGFR change. After multivariable adjustment of baseline covariates, including baseline eGFR, seven of the 13 metabolites, including cysteine, long-chain acylcarnitines (C14:1OH, C18, C18:2, and C20:4), and other acylcarnitines (C3DC and C10), were significantly associated with incident reduced eGFR (relative risks ranged from 1.16 to 1.25 per SD increment of metabolites; P<3.8E-03 after Bonferroni correction of multiple testing of the 13 metabolites). Moreover, principal component analysis identified two factors, consisting of cysteine and long-chain acylcarnitines, respectively, that were associated with incident reduced eGFR. Conclusions Elevated plasma levels of cysteine and a panel of acylcarnitines were associated with a higher incidence of reduced eGFR in Chinese adults, independent of baseline eGFR and other conventional risk factors.
学科主题Urology & Nephrology
WOS关键词CHRONIC KIDNEY-DISEASE ; HIGH-FAT DIET ; GENERAL-POPULATION ; NONCOMMUNICABLE DISEASES ; METABOLOMIC PROFILES ; INSULIN-RESISTANCE ; FUNCTION DECLINE ; RENAL-FUNCTION ; OLDER CHINESE ; EQUATION
语种英语
WOS记录号WOS:000429693100009
出版者AMER SOC NEPHROLOGY
版本出版稿
源URL[http://202.127.25.144/handle/331004/635]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,Shanghai Institutes for Biological Sciences, CAS
2.Inst Nutr Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China. Chinese Academy of Sciences;
推荐引用方式
GB/T 7714		 Wang, Feijie,Sun, Liang,Sun, Qi,et al. Associations of Plasma Amino Acid and Acylcarnitine Profiles with Incident Reduced Glomerular Filtration Rate[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2018,13(4):560-568.
APA Wang, Feijie.,Sun, Liang.,Sun, Qi.,Liang,Liming.,Gao, Xianfu.,...&Lin,Xu.(2018).Associations of Plasma Amino Acid and Acylcarnitine Profiles with Incident Reduced Glomerular Filtration Rate.CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,13(4),560-568.
MLA Wang, Feijie,et al."Associations of Plasma Amino Acid and Acylcarnitine Profiles with Incident Reduced Glomerular Filtration Rate".CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13.4(2018):560-568.

入库方式： OAI收割

来源：上海营养与健康研究所

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