Cilia loss sensitizes cells to transformation by activating the mevalonate pathway
文献类型：期刊论文
| 作者 | Deng, Yue-Zhen3,6; Cai, Zhen3; Shi, Shuo3; Jiang, Hao3; Shang, Yu-Rong3; Ma, Ning3; Wang, Jing-Jing3; Guan, Dong-Xian3; Chen, Tian-Wei3; Qian, Zhen-Yu3 |
| 刊名 | JOURNAL OF EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2018 |
| 卷号 | 215期号:1页码:177-195 |
| 关键词 | GRIA1 GRIK4 GRM7 major depressive disorder response venlafaxine |
| ISSN号 | 0022-1007 |
| DOI | 10.1084/jem.20170399 |
| 文献子类 | Article |
| 英文摘要 | Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transformation of normal pancreatic cells (HPDE6C7) and NIH3T3 cells through activating the mevalonate (MVA) pathway. Disruption of ciliogenesis up-regulated MVA enzymes through beta-catenin-T cell factor (TCF) signaling, which synchronized with sterol regulatory element binding transcription factor 2 (SREBP2), and the regulation of MVA by beta-catenin-TCF signaling was recapitulated in a mouse model of pancreatic ductal adenocarcinoma (PDAC) and human PDAC samples. Moreover, disruption of ciliogenesis by depleting Tg737 dramatically promoted tumorigenesis in the PDAC mouse model, driven by Kras(G12D), which was inhibited by statin, an inhibitor of the MVA pathway. Collectively, this study emphasizes the crucial roles of cilia in governing the early steps of the transformation by activating the MVA pathway, suggesting that statin has therapeutic potential for pancreatic cancer treatment. |
| 学科主题 | Immunology ; Research & Experimental Medicine |
| WOS关键词 | LOVASTATIN-INDUCED APOPTOSIS ; CANCER METABOLISM ; PANCREATIC-CANCER ; STATIN THERAPY ; PROLIFERATION ; AUTOPHAGY ; CILIOGENESIS ; INHIBITION ; REDUCTASE ; COENZYME |
| 语种 | 英语 |
| WOS记录号 | WOS:000419134400015 |
| 出版者 | ROCKEFELLER UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/636]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Southern Med Univ, Dept Gen Surg, Fengxian Hosp, Shanghai, Peoples R China, 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 3.Chinese Acad Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China; 5.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Inst Hlth Sci,Shanghai Inst Biol Sci, Shanghai, Peoples R China; 6.Cent S Univ, Xiangya Hosp, Ctr Mol Med, Changsha, Hunan, Peoples R China; 7.Fudan Univ, Zhongshan Hosp, Gen Surg Dept, Pancreat Canc Grp, Shanghai, Peoples R China; 8.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China; 9.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC USA; |
| 推荐引用方式 GB/T 7714 | Deng, Yue-Zhen,Cai, Zhen,Shi, Shuo,et al. Cilia loss sensitizes cells to transformation by activating the mevalonate pathway[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2018,215(1):177-195. |
| APA | Deng, Yue-Zhen.,Cai, Zhen.,Shi, Shuo.,Jiang, Hao.,Shang, Yu-Rong.,...&,.(2018).Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.JOURNAL OF EXPERIMENTAL MEDICINE,215(1),177-195. |
| MLA | Deng, Yue-Zhen,et al."Cilia loss sensitizes cells to transformation by activating the mevalonate pathway".JOURNAL OF EXPERIMENTAL MEDICINE 215.1(2018):177-195. |
入库方式： OAI收割
来源：上海营养与健康研究所
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