Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
文献类型：期刊论文
| 作者 | Lei, Tingjun3; Zhang, Peixuan3; Zhang, Xudong3; Zhu, Xiaofeng3; Li, Qintong3; Xiao, Xue4; Min, Ling4; Yin, Rutie4; Zhang, Jingli5; Li, Qian5 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:-页码:1876 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-04258-w |
| 文献子类 | Article |
| 英文摘要 | The assembly of prereplicative complex (pre-RC) during G1 phase must be tightly controlled to sustain cell proliferation and maintain genomic stability. Mechanisms to prevent pre-RC formation in G2/M and S phases are well appreciated, whereas how cells ensure efficient pre-RC assembly during G1 is less clear. Here we report that cyclin K regulates pre-RC formation. We find that cyclin K expression positively correlates with cell proliferation, and knockdown of cyclin K or its cognate kinase CDK12 prevents the assembly of pre-RC in G1 phase. Mechanistically we uncover that cyclin K promotes pre-RC assembly by restricting cyclin E1 activity in G1. We identify a cyclin K-dependent, novel phosphorylation site in cyclin E1 that disrupts its interaction with CDK2. Importantly, this antagonistic relationship is largely recapitulated in cyclin E1-overexpressing tumors. We discuss the implications of our findings in light of recent reports linking cyclin K and CDK12 to human tumorigenesis. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | RNA-POLYMERASE-II ; EMBRYONIC STEM-CELLS ; DNA-DAMAGE RESPONSE ; CHROMOSOME INSTABILITY ; LIVER-REGENERATION ; GENOMIC STABILITY ; TERMINAL DOMAIN ; OVARIAN-CANCER ; REPLICATION ; KINASE |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000431960400014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/638]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Sichuan Cunde Therapeut, Chengdu 610093, Sichuan, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Mol Cell Sci,Inst Hlth Sci, Key Lab Stem Cell Biol,Chinese Acad Sci, Shanghai 200031, Peoples R China, 3.Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, State Key Lab Biotherapy & Collaborat Innovat Ctr, Dept Obstet & Gynecol,West China Univ Hosp 2,Coll, Chengdu 610041, Sichuan, Peoples R China; 4.Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China; 5.Hosp 363 Aviat Ind Corp China, Dept Pathol, Chengdu 610041, Sichuan, Peoples R China; 6.Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu 610041, Sichuan, Peoples R China; 7.Sichuan Univ, Coll Life Sci, Ctr Growth Metab & Aging, Key Lab Bioresource & Ecoenvironm,Minist Educ, Chengdu 610064, Sichuan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lei, Tingjun,Zhang, Peixuan,Zhang, Xudong,et al. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation[J]. NATURE COMMUNICATIONS,2018,9(-):1876. |
| APA | Lei, Tingjun.,Zhang, Peixuan.,Zhang, Xudong.,Zhu, Xiaofeng.,Li, Qintong.,...&,.(2018).Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.NATURE COMMUNICATIONS,9(-),1876. |
| MLA | Lei, Tingjun,et al."Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation".NATURE COMMUNICATIONS 9.-(2018):1876. |
入库方式： OAI收割
来源：上海营养与健康研究所
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