Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency
文献类型：期刊论文
| 作者 | Yao, Pang1,3; Sun, Liang1,3; Xiong, Quan1,3; Li, Huaixing1,3; Lin, Xu1,3; Xu, Xinming2; , |
| 刊名 | JOURNAL OF NUTRITION
 |
| 出版日期 | 2018 |
| 卷号 | 148期号:5页码:746-751 |
| 关键词 | cholecalciferol bone turnover markers randomized placebo-controlled trial |
| ISSN号 | 0022-3166 |
| DOI | 10.1093/jn/nxy032 |
| 文献子类 | Article |
| 英文摘要 | Background: Bone turnover markers (BTMs) are proposed as alternative indicators for bone mineral density in diagnosis and management of osteoporosis. However, little is known about the effects of vitamin D supplementation on BTMs in nonwhite populations. Objective: We aimed to investigate the responses in BTMs after vitamin D supplementation in Asians. Methods: In this secondary data analysis of a randomized, double-blind, placebo-controlled trial, 448 Chinese adults [mean +/- SD age: 31.9 +/- 8.0 y; mean +/- SD body mass index (kg/m(2)): 22.1 +/- 2.6; 69% were women] with vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] <50 nmol/L) received 2000 IU/d cholecalciferol or placebo for 20 wk. Serum concentrations of 25(OH)D, parathyroid hormone (PTH), calcium, and markers of bone formation and resorption were measured at weeks 0 and 20. Intention-to-treat analysis was applied, and between-group differences were compared by general linear models with adjustments. Results: Cholecalciferol supplementation increased the serum bone alkaline phosphatase (BALP) concentration (+1.7 +/- 1.9 mu g/L) significantly more than placebo (+1.1 +/- 1.7 mu g/L; P= 0.004), but not circulating concentrations of procollagen type I N-terminal propeptide (PINP), beta-isomerized C-terminal telopeptide of type I collagen (beta-CTX), or tartrate-resistant acid phosphatase 5b (TRAP5b) (P >= 0.53). Notably, a pooled analysis indicated that changes in serum 25(OH)D were positively associated with changes in serum BALD PINP and TRAP5b (r = 0.07-0.16, P <= 0.02), but inversely with changes in PTH (r= -0.15, P < 0.001). Among cholecalciferol-treated participants, individuals who achieved serum 25(OH)D >= 75 nmol/L had greater increases in serum beta-CTX (224% compared with 146%; P= 0.02) and TRAP5b (22.2% compared with 9.1%; P = 0.007), but smaller decreases in serum calcium (-1.3% compared with -1.9%; P = 0.005) and calcium-phosphorus product (-2.6% compared with -3.3%; P= 0.02) compared with those with serum 25(OH)D <75 nmol/L. Conclusions: Daily supplementation with 2000 IU cholecalciferol for 20 wk may promote bone formation in Chinese adults with vitamin D deficiency. More studies are needed to elucidate the potential clinical implications of BTMs. |
| 学科主题 | Nutrition & Dietetics |
| WOS关键词 | 25-HYDROXYVITAMIN D CONCENTRATION ; D-FORTIFIED MILK ; POSTMENOPAUSAL WOMEN ; METABOLIC SYNDROME ; RACIAL-DIFFERENCES ; CLINICAL-PRACTICE ; OSTEOPOROSIS ; MARKERS ; CALCIUM ; DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000431895200010 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/640]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China; 2.Fudan Univ, Sch Publ Hlth, Minist Educ, Key Lab Publ Hlth Safety, Shanghai, Peoples R China, 3.Univ Chinese Acad Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yao, Pang,Sun, Liang,Xiong, Quan,et al. Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency[J]. JOURNAL OF NUTRITION,2018,148(5):746-751. |
| APA | Yao, Pang.,Sun, Liang.,Xiong, Quan.,Li, Huaixing.,Lin, Xu.,...&,.(2018).Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency.JOURNAL OF NUTRITION,148(5),746-751. |
| MLA | Yao, Pang,et al."Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency".JOURNAL OF NUTRITION 148.5(2018):746-751. |
入库方式： OAI收割
来源：上海营养与健康研究所
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