Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21
文献类型：期刊论文
| 作者 | Han, Yamei3; Zhang, Feifei3; Hu, Zhimin3; Cui, Aoyuan3; Ma, Fengguang3; Liu, Zhengshuai3; Gong, Qi3; Chen, Xuqing3; Gao, Jing3; Li, Yu3 |
| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 175期号:2页码:374-387 |
| 关键词 | Dorsomorphin heat shock factor 1 heat shock protein apoptosis cancer |
| ISSN号 | 0007-1188 |
| DOI | 10.1111/bph.14079 |
| 文献子类 | Article |
| 英文摘要 | Background and PurposeBerberine, a compound from rhizome coptidis, is traditionally used to treat gastrointestinal infections, such as bacterial diarrhoea. Recently, berberine was shown to have hypoglycaemic and hypolipidaemic effects. We investigated the mechanisms by which berberine regulates hepatic lipid metabolism and energy expenditure in mice. Experimental ApproachLiver-specific SIRT1 knockout mice and their wild-type littermates were fed a high-fat, high-sucrose (HFHS) diet and treated with berberine by i.p. injection for fiveweeks. Mouse primary hepatocytes and human HepG2 cells were treated with berberine and then subjected to immunoblotting analysis and Oil Red O staining. Key ResultsBerberine attenuated hepatic steatosis and controlled energy balance in mice by inducing autophagy and FGF21. These beneficial effects of berberine on autophagy and hepatic steatosis were abolished by a deficiency of the nutrient sensor SIRT1 in the liver of HFHS diet-fed obese mice and in mouse primary hepatocytes. SIRT1 is essential for berberine to potentiate autophagy and inhibit lipid storage in mouse livers in response to fasting. Mechanistically, the berberine stimulates SIRT1 deacetylation activity and induces autophagy in an autophagy protein 5-dependent manner. Moreover, the administration of berberine was shown to promote hepatic gene expression and circulating levels of FGF21 and ketone bodies in mice in a SIRT1-dependent manner. Conclusions and ImplicationsBerberine acts in the liver to regulate lipid utilization and maintain whole-body energy metabolism by mediating autophagy and FGF21 activation. Hence, it has therapeutic potential for treating metabolic defects under nutritional overload, such as fatty liver diseases, type 2 diabetes and obesity. |
| 学科主题 | Pharmacology & Pharmacy |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; FATTY LIVER-DISEASE ; LIPID-METABOLISM ; CALORIE RESTRICTION ; INSULIN SENSITIVITY ; OXIDATIVE STRESS ; CONCISE GUIDE ; PPAR-ALPHA ; CELL-DEATH ; SIRT1 |
| 语种 | 英语 |
| WOS记录号 | WOS:000419599900016 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/641]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Fudan Inst Metab Dis, Shanghai, Peoples R China; 2.Univ Louisville, Dept Pediat, Pediat Res Inst, Wendy L Novak Diabet Care Ctr, Louisville, KY 40292 USA, 3.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, CAS Key Lab Nutr & Metab,Inst Nutr Sci, 320 Yue Yang Rd,Life Sci Res Bldg A1816, Shanghai 200031, Peoples R China; 4.Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, 180 Fenglin Rd, Shanghai 200032, Peoples R China; 5.Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Sch Pharmaceut Sci, Wenzhou, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Han, Yamei,Zhang, Feifei,Hu, Zhimin,et al. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21[J]. BRITISH JOURNAL OF PHARMACOLOGY,2018,175(2):374-387. |
| APA | Han, Yamei.,Zhang, Feifei.,Hu, Zhimin.,Cui, Aoyuan.,Ma, Fengguang.,...&,.(2018).Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21.BRITISH JOURNAL OF PHARMACOLOGY,175(2),374-387. |
| MLA | Han, Yamei,et al."Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21".BRITISH JOURNAL OF PHARMACOLOGY 175.2(2018):374-387. |
入库方式： OAI收割
来源：上海营养与健康研究所
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