Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis
文献类型：期刊论文
| 作者 | Li, Jing-Jing3; Yin, Hong-Kun3; Guan, Dong-Xian3; Zhao, Jiang-Sha3; Feng, Yu-Xiong3; Deng, Yue-Zhen3; Xie, Dong3; Wang, Xiang4; Bao, Ying4; Li, Nan1 |
| 刊名 | BRITISH JOURNAL OF CANCER
 |
| 出版日期 | 2018 |
| 卷号 | 118期号:10页码:1337-1348 |
| 关键词 | snoRNA cancer type Monte Carlo feature selection support vector machine RIPPER algorithm |
| ISSN号 | 0007-0920 |
| DOI | 10.1038/s41416-018-0077-y |
| 文献子类 | Article |
| 英文摘要 | BACKGROUND: Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS: Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and mechanism study. Mouse models of extrahepatic and intrahepatic metastasis were employed to evaluate the therapeutic potential of chemerin. RESULTS: Chemerin expression was significantly downregulated in hepatocellular carcinoma, and associated with poor prognosis of HCC patients. Forced expression of chemerin inhibited in vitro migration, invasion and in vivo metastasis of HCC cells. Administration of chemerin effectively suppressed extrahepatic and intrahepatic metastases of HCC cells, resulting in prolonged survival of tumour-bearing nude mice. Chemerin upregulated expression and phosphatase activity of PTEN by interfering with PTEN-CMKLR1 interaction, leading to weakened ubiquitination of PTEN and decreased p-Akt (Ser473) level, which was responsible for suppressed migration, invasion and metastasis of HCC cells. Positive correlation between chemerin and PTEN, and reverse correlation between chemerin and p-Akt (Ser473) were also observed in HCC clinical samples and intrahepatic mouse model in vivo. CONCLUSIONS: Our study has revealed the suppressive role and therapeutic potential of chemerin in HCC metastasis, providing both a prognostic marker and drug candidate for HCC. |
| 学科主题 | Oncology |
| WOS关键词 | DENDRITIC CELLS ; DOWN-REGULATION ; IN-VIVO ; EXPRESSION ; UBIQUITINATION ; ESTABLISHMENT ; STIMULATION ; MACROPHAGES ; PROGNOSIS ; SURVIVAL |
| 语种 | 英语 |
| WOS记录号 | WOS:000435643400009 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/643]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Second Mil Med Univ, Eastern Hepatobililary Surg Hosp, 225 Changhai Rd, Shanghai 200433, Peoples R China; 2.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China, 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr Metab & Food Safety, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 4.Huzhou Univ, Peoples Hosp Affiliated 1, Dept Surg, Huzhou 313000, Peoples R China; 5.Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA; |
| 推荐引用方式 GB/T 7714 | Li, Jing-Jing,Yin, Hong-Kun,Guan, Dong-Xian,et al. Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis[J]. BRITISH JOURNAL OF CANCER,2018,118(10):1337-1348. |
| APA | Li, Jing-Jing.,Yin, Hong-Kun.,Guan, Dong-Xian.,Zhao, Jiang-Sha.,Feng, Yu-Xiong.,...&,.(2018).Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.BRITISH JOURNAL OF CANCER,118(10),1337-1348. |
| MLA | Li, Jing-Jing,et al."Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis".BRITISH JOURNAL OF CANCER 118.10(2018):1337-1348. |
入库方式： OAI收割
来源：上海营养与健康研究所
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