Comparative transcriptomics reveals specific responding genes associated with atherosclerosis in rabbit and mouse models
文献类型：期刊论文
| 作者 | Wu, Leilei1; Yao, Qianlan1; Li, Yixue1,3; Lin, Ping3; Li, Hong3; Li, Yixue2; , |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2018 |
| 卷号 | 13期号:8页码:e0201618 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0201618 |
| 文献子类 | Article |
| 英文摘要 | Mouse and rabbit are frequently employed species for atherosclerosis research. With respect to modeling human atherosclerosis, it has been observed that variations in phenotype under commonly used atherogenic conditions are partial or no congruence between two species. However, genome-wide molecular variations are still lacking. To understand the differences between rabbit and mouse in developing atherosclerosis, here from aspect of orthologs, we compared the genome-wide expression profiles of two species under the same atherosclerosis driven factors: high-fat diet or LDLR deficiency. Our results illuminated that: 1) LDLR-deficiency induced different gene expression changes in rabbit and mouse. WHHL rabbit had more significantly differential expressed genes and the most of genes were down-regulated. 2) Some genes and functions were commonly dysregulated in high-fat fed rabbit and mouse models, such as lipid metabolism and inflammation process. However, high-fat intake in rabbit produced more differentially expressed genes and more serious functional effects. 3) Specific differential expression genes were revealed for rabbit and mouse related with high-fat intake. In the aspect of lipoprotein metabolism, APOA4 and APOB was the major responding gene in rabbit and mice, respectively. The expression change of APOA4 and APOB in human atherosclerosis was more similar to rabbit, and therefore rabbit might be a better animal model for investigating human lipoprotein metabolism related diseases. In conclusion, our comparative transcriptome analysis revealed species-specific expression regulation that could partially explain the different phenotypes between rabbit and mouse, which was helpful for model selection to study atherosclerosis. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | FAMILIAL HYPERCHOLESTEROLEMIA ; RISK-FACTORS ; LIVER ; EXPRESSION ; MICE ; LIPOPROTEINS ; METABOLISM ; MECHANISMS ; SECRETION ; PROTEINS |
| 语种 | 英语 |
| WOS记录号 | WOS:000440415500102 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/647]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai, Peoples R China; 2.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China, 3.Univ Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Chinese Acad Sci,CAS Key Lab Computat Biol, Shanghai Inst Biol Sci,Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Leilei,Yao, Qianlan,Li, Yixue,et al. Comparative transcriptomics reveals specific responding genes associated with atherosclerosis in rabbit and mouse models[J]. PLOS ONE,2018,13(8):e0201618. |
| APA | Wu, Leilei.,Yao, Qianlan.,Li, Yixue.,Lin, Ping.,Li, Hong.,...&,.(2018).Comparative transcriptomics reveals specific responding genes associated with atherosclerosis in rabbit and mouse models.PLOS ONE,13(8),e0201618. |
| MLA | Wu, Leilei,et al."Comparative transcriptomics reveals specific responding genes associated with atherosclerosis in rabbit and mouse models".PLOS ONE 13.8(2018):e0201618. |
入库方式： OAI收割
来源：上海营养与健康研究所
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