Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques
文献类型：期刊论文
| 作者 | Mazin, Pavel V.2,3,4; Fu, Ning2; Gelfand, Mikhail S.2,3,4; Khaitovich, Philipp2,5,6; Jiang, Xi5; Han, Dingding5; Guo, Meng5; Guo, Meng1,6; Gelfand, Mikhail S.7; Khaitovich, Philipp8 |
| 刊名 | RNA
 |
| 出版日期 | 2018 |
| 卷号 | 24期号:4页码:585-596 |
| ISSN号 | 1355-8382 |
| 关键词 | transcriptomics RNA-seq alternative splicing brain development |
| DOI | 10.1261/rna.064931.117 |
| 文献子类 | Article |
| 英文摘要 | Changes in splicing are known to affect the function and regulation of genes. We analyzed splicing events that take place during the postnatal development of the prefrontal cortex in humans, chimpanzees, and rhesus macaques based on data obtained from 168 individuals. Our study revealed that among the 38,822 quantified alternative exons, 15% are differentially spliced among species, and more than 6% splice differently at different ages. Mutations in splicing acceptor and/or donor sites might explain more than 14% of all splicing differences among species and up to 64% of high-amplitude differences. A reconstructed trans-regulatory network containing 21 RNA-binding proteins explains a further 4% of splicing variations within species. While most age-dependent splicing patterns are conserved among the three species, developmental changes in intron retention are substantially more pronounced in humans. |
| 学科主题 | Biochemistry & Molecular Biology |
| WOS关键词 | INTRON RETENTION ; BRAIN ; IDENTIFICATION ; MECHANISMS ; EXPRESSION ; DATABASE ; UPDATE ; GENE ; RNAS |
| 语种 | 英语 |
| 出版者 | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| WOS记录号 | WOS:000428085200012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/651]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.Skolkovo Inst Sci & Technol, Ctr Data Intens Biomed & Biotechnol, Moscow 143028, Russia; 3.Russian Acad Sci, Inst Informat Transmiss Problems, Kharkevich Inst, Moscow 127051, Russia; 4.Higher Sch Econ, Fac Comp Sci, Moscow 125319, Russia; 5.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; 7.Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow 119992, Russia; 8.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany, |
| 推荐引用方式 GB/T 7714 | Mazin, Pavel V.,Fu, Ning,Gelfand, Mikhail S.,et al. Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques[J]. RNA,2018,24(4):585-596. |
| APA | Mazin, Pavel V..,Fu, Ning.,Gelfand, Mikhail S..,Khaitovich, Philipp.,Jiang, Xi.,...&,.(2018).Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques.RNA,24(4),585-596. |
| MLA | Mazin, Pavel V.,et al."Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques".RNA 24.4(2018):585-596. |
入库方式： OAI收割
来源：上海营养与健康研究所
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