中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques

文献类型:期刊论文

AuthorMazin, Pavel V.2,3,4; Fu, Ning2; Gelfand, Mikhail S.2,3,4; Khaitovich, Philipp2,5,6; Jiang, Xi5; Han, Dingding5; Guo, Meng5; Guo, Meng1,6; Gelfand, Mikhail S.7; Khaitovich, Philipp8
SourceRNA
Issued Date2018
Volume24Issue:4Pages:585-596
Keywordtranscriptomics RNA-seq alternative splicing brain development
ISSN1355-8382
DOI10.1261/rna.064931.117
SubtypeArticle
English AbstractChanges in splicing are known to affect the function and regulation of genes. We analyzed splicing events that take place during the postnatal development of the prefrontal cortex in humans, chimpanzees, and rhesus macaques based on data obtained from 168 individuals. Our study revealed that among the 38,822 quantified alternative exons, 15% are differentially spliced among species, and more than 6% splice differently at different ages. Mutations in splicing acceptor and/or donor sites might explain more than 14% of all splicing differences among species and up to 64% of high-amplitude differences. A reconstructed trans-regulatory network containing 21 RNA-binding proteins explains a further 4% of splicing variations within species. While most age-dependent splicing patterns are conserved among the three species, developmental changes in intron retention are substantially more pronounced in humans.
SubjectBiochemistry & Molecular Biology
WOS KeywordINTRON RETENTION ; BRAIN ; IDENTIFICATION ; MECHANISMS ; EXPRESSION ; DATABASE ; UPDATE ; GENE ; RNAS
Language英语
PublisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
WOS IDWOS:000428085200012
Version出版稿
源URL[http://202.127.25.144/handle/331004/651]  
Collection中国科学院上海生命科学研究院营养科学研究所
Affiliation1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
2.Skolkovo Inst Sci & Technol, Ctr Data Intens Biomed & Biotechnol, Moscow 143028, Russia;
3.Russian Acad Sci, Inst Informat Transmiss Problems, Kharkevich Inst, Moscow 127051, Russia;
4.Higher Sch Econ, Fac Comp Sci, Moscow 125319, Russia;
5.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China;
6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
7.Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow 119992, Russia;
8.Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany,
Recommended Citation
GB/T 7714
Mazin, Pavel V.,Fu, Ning,Gelfand, Mikhail S.,et al. Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques[J]. RNA,2018,24(4):585-596.
APA Mazin, Pavel V..,Fu, Ning.,Gelfand, Mikhail S..,Khaitovich, Philipp.,Jiang, Xi.,...&,.(2018).Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques.RNA,24(4),585-596.
MLA Mazin, Pavel V.,et al."Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees, and macaques".RNA 24.4(2018):585-596.

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来源:上海营养与健康研究所

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