SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug
文献类型：期刊论文
| 作者 | Song, Lele1,3; Chang, Renxu1,3; Dai, Cheng1,3; Wu, Yanjun1,3; Guo, Jingyu1,3; Qi, Meiyan1; Zhan, Lixing1; Zhou, Wu2; , |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:6页码:9108-9122 |
| 关键词 | SORBS1 migration invasion JNK cisplatin sensitivity |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.12851 |
| 文献子类 | Article |
| 英文摘要 | Tumor metastasis and invasion are both hallmarks of cancer malignancy and the leading cause of cancer death. Here we show that the adaptor protein SORBS1 (Sorbin and SH3 domain-containing protein 1, also known as CAP/ponsin) is expressed at low levels in clinical cancer samples. In addition, low-level expression of SORBS1 was significantly associated with poor clinical outcomes and the increased tumor cell invasive capacity in breast cancer patients. We demonstrate that depletion of SORBS1 increases protrusions and filopodium-like protrusions (FLPs) formation, as well as the migratory and invasive abilities of cancer cells, via activation of JNK/cJun. Furthermore, silencing of SORBS1 promotes the epithelial-to-mesenchymal transition (EMT) process and attenuates chemical drug sensitivity especially that to cisplatin, by inhibition of p53 in breast cancer cells. Thus, we illustrate that SORBS1 is a potential inhibitor of metastasis in cancer and may be a promising target in chemotherapy. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | GLUT4 TRANSLOCATION REQUIRES ; CBL-ASSOCIATED PROTEIN ; BREAST-CANCER ; MESENCHYMAL TRANSITION ; SIGNAL-TRANSDUCTION ; PANCREATIC-CANCER ; EPITHELIAL-CELLS ; ADAPTER PROTEIN ; MAPK PATHWAYS ; C-ABL |
| 语种 | 英语 |
| WOS记录号 | WOS:000394181800020 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/654]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab food safety Res, Shanghai 200031, Peoples R China; 2.Lishui Univ, Dept Med, Coll Med & Hlth, Lishui 323000, Peoples R China, 3.Univ Chinese Acad Sci, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Song, Lele,Chang, Renxu,Dai, Cheng,et al. SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug[J]. ONCOTARGET,2017,8(6):9108-9122. |
| APA | Song, Lele.,Chang, Renxu.,Dai, Cheng.,Wu, Yanjun.,Guo, Jingyu.,...&,.(2017).SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug.ONCOTARGET,8(6),9108-9122. |
| MLA | Song, Lele,et al."SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug".ONCOTARGET 8.6(2017):9108-9122. |
入库方式： OAI收割
来源：上海营养与健康研究所
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