Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion
文献类型：期刊论文
| 作者 | Yang, Lili3; Hao, Shijun3; Song, Haiyan3; Liu, Tao3; Zheng, Peiyong3; Lin, Weili1,4; Nugent, Colleen A.2; , |
| 刊名 | INTERNATIONAL JOURNAL OF GENOMICS
 |
| 出版日期 | 2017 |
| 卷号 | -期号:-页码:2790864 |
| 关键词 | extracellular matrix hypertension hypoxia macrophages transforming growth factor |
| ISSN号 | 2314-436X |
| DOI | 10.1155/2017/2790864 |
| 文献子类 | Article |
| 英文摘要 | Background. Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of liver transplantation. Lingguizhugan decoction (LGZG), a classical Chinese herbal formula, has beneficial effects on NAFLD animal models. Our study examined the impact of LGZG on hepatic global transcriptome of high-fat-diet-induced NAFLD rats. Methods. Three groups of Wistar rats were included: normal, NAFLD model, and LGZG-treated NAFLD groups. Four weeks for the treatment, liver tissues were harvested for RNA sequencing. Differentially expressed genes (DEGs) and enriched pathways were detected on hepatic global transcriptome profile. Real-time PCR validated the regulatory patterns of LGZG on NAFLD rats. Results. DEGs between the NAFLD model and normal groups indicated the elevated peroxisome proliferator-activated receptor (PPAR) and hedgehog signaling pathways in NAFLD rats. In bile secretion pathway, genes involved in cholesterol secretion were activated by LGZG treatment. Increased expression of antioxidant OSIGN1 and decreased expression of genes (AHR, IRF2BP2, and RASGEF1B) that induce oxidative stress and inflammation were observed in NAFLD rats treated with LGZG. The regulatory patterns of LGZG treatment on these oxidative stress-related genes were confirmed by real-time PCR. Conclusion. Our study revealed a "two-hits-targeting" mechanism of LGZG in the treatment for NAFLD: alleviating oxidative stress and activating cholesterol secretion. |
| 学科主题 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; STEAROYL-COA DESATURASE ; STEATOHEPATITIS ; EXPRESSION ; NAFLD ; ALCOHOL ; MICE ; PIOGLITAZONE ; CONNECTION ; METABOLISM |
| 语种 | 英语 |
| WOS记录号 | WOS:000418948600001 |
| 出版者 | HINDAWI LTD |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/659]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.SUNY Buffalo, Women & Childrens Hosp Buffalo, Digest Dis & Nutr Ctr, Dept Pediat, Buffalo, NY 14214 USA, 3.Shanghai Univ Tradit Chinese Med, Longhua Hosp, China Canada Ctr Res Digest Dis, Inst Digest Dis, Shanghai 200032, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yang, Lili,Hao, Shijun,Song, Haiyan,et al. Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion[J]. INTERNATIONAL JOURNAL OF GENOMICS,2017,-(-):2790864. |
| APA | Yang, Lili.,Hao, Shijun.,Song, Haiyan.,Liu, Tao.,Zheng, Peiyong.,...&,.(2017).Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion.INTERNATIONAL JOURNAL OF GENOMICS,-(-),2790864. |
| MLA | Yang, Lili,et al."Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion".INTERNATIONAL JOURNAL OF GENOMICS -.-(2017):2790864. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。