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Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism

文献类型：期刊论文

作者Wang, Lu4,5; Wang, Zejun4,5; Zhang, Yi4,5; Yin, Min4,5; Li, Jiang4,5; Shi, Jiye4,5; Wang, Lihua4,5; Chen, Nan4,5; Fan, Chunhai1,4,5; Li, Xiaoming1
刊名NANO RESEARCH
出版日期2018
卷号11期号:5页码:2746-2755
关键词catalase-like activity iron oxide nanoparticles autophagy cytotoxicity reactive oxygen species
ISSN号1998-0124
DOI10.1007/s12274-017-1905-8
文献子类Article
英文摘要Magnetite nanoparticles (Fe3O4 NPs) are a well proven biocompatible nanomaterial, which hold great promise in various biomedical applications. Interestingly, unlike conventional biocompatible materials (e.g., polyethylene glycol (PEG)) that are chemically and biologically inert in nature, Fe3O4 NPs are known to be catalytically active and exhibit prominent physiological effects. Herein, we report an "active", dynamic equilibrium mechanism for maintaining the cellular amenity of Fe3O4 NPs. We examined the effects of two types of iron oxide (magnetite and hematite) NPs in rat pheochromocytoma (PC12) cells and found that both induced stress responses. However, only Fe2O3 NPs caused significant programmed cell death; whereas Fe3O4 NPs are amenable to cells. We found that intrinsic catalase-like activity of Fe3O4 NPs antagonized the accumulation of toxic reactive oxygen species (ROS) induced by themselves, and thereby modulated the extent of cellular oxidative stress, autophagic activity, and programmed cell death. In line with this observation, we effectively reversed severe autophagy and cell death caused by Fe2O3 NPs via co-treatment with natural catalase. This study not only deciphers the distinct intrinsic antagonism of Fe3O4 NPs, but opens new routes to designing biocompatible theranostic nanoparticles with novel mechanisms.
学科主题Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS关键词MESENCHYMAL STEM-CELLS ; MAGNETIC NANOPARTICLES ; INDUCED AUTOPHAGY ; OXIDATIVE STRESS ; CANCER-CELLS ; IN-VITRO ; CYTOTOXICITY ; APOPTOSIS ; GRAPHENE ; THERAPY
语种英语
WOS记录号WOS:000431999700039
出版者TSINGHUA UNIV PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/660]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
2.UCB Pharma, 208 Bath Rd, Slough SL1 3WE, Berks, England;
3.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China,
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China;
6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Wang, Lu,Wang, Zejun,Zhang, Yi,et al. Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism[J]. NANO RESEARCH,2018,11(5):2746-2755.
APA Wang, Lu.,Wang, Zejun.,Zhang, Yi.,Yin, Min.,Li, Jiang.,...&,.(2018).Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism.NANO RESEARCH,11(5),2746-2755.
MLA Wang, Lu,et al."Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism".NANO RESEARCH 11.5(2018):2746-2755.

入库方式： OAI收割

来源：上海营养与健康研究所

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