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The Safety of Ovarian Preservation in Stage I Endometrial Endometrioid Adenocarcinoma Based on Propensity Score Matching

文献类型：期刊论文

作者Hou, Ting1,2; Li, Yixue1,2,4; Sun, Yidi2; Li, Junyi2; Wang, Zhen2; Liu, Chenglin4; Lu, Yuan3; ,
刊名COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
出版日期2017
卷号20期号:7页码:647-655
关键词Premenopausal women endometrioid adenocarcinoma propensity score matching ovarian preservation
ISSN号1386-2073
DOI10.2174/1386207320666170417145856
文献子类Article
英文摘要Background: Most patients with early stage endometrial endometrioid adenocarcinoma (EEAC) are treated with hysterectomy and bilateral oophorectomy. But this surgical menopause leads to long-term sequelae for premenopausal women, especially for young women of childbearing age. This population-based study was to evaluate the safety of ovarian preservation in young women with stage I EEAC. Methods: Patients of age 50 or younger with stage I EEAC were explored from the Surveillance, Epidemiology and End Results program database during 2004 to 2013. Propensity score matching was used to randomize the data set and reduce the selection biases of doctors. Univariate analysis and multivariate cox proportional hazards model were utilized to estimate the safety of ovarian preservation. Results: A total of 7183 patients were identified, and ovarian preservation was performed in 863 (12 %) patients. Compared with women treated with oophorectomy, patients with ovarian preservation significantly tend to be younger at diagnosis (P-value < 0.001) and more likely diagnosed as stage IA EEAC, to have better differentiated tumor tissues and smaller tumors, as well as less likely to undergo radiation and lymphadenectomy. 863 patients treated with oophorectomy were selected by propensity score matching. After propensity score matching, the differences of all characteristics between ovarian preservation and oophorectomy were not significant and potential confounders in the two groups decreased. In univariate analysis of matched population, ovarian preservation had no effect on overall (P-value=0.928) and cancer-specific (P-value=0.390) mortality. In propensity-adjusted multivariate analysis, ovarian preservation was not significantly associated with overall (HR=0.69, 95% CI=0.41-1.68, P-value=0.611) and cancer-specific (HR=1.65, 95% CI=0.54-5.06, Pvalue=0.379) survival. Conclusion: Ovarian preservation is safe for young women with stage I EEAC, which is not significantly associated with overall and cancer-specific mortality.
学科主题Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
WOS关键词GYNECOLOGIC-ONCOLOGY-GROUP ; YOUNG-WOMEN ; HYSTEROSCOPIC RESECTION ; ATYPICAL HYPERPLASIA ; CANCER ; RISK ; HYSTERECTOMY ; OOPHORECTOMY ; METAANALYSIS ; GUIDELINES
语种英语
WOS记录号WOS:000413458200009
出版者BENTHAM SCIENCE PUBL LTD
版本出版稿
源URL[http://202.127.25.144/handle/331004/661]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.East China Univ Sci & Technol, Sch Biol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
3.Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, 419 Fangxie Rd, Shanghai 200011, Peoples R China,
4.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China;
推荐引用方式
GB/T 7714		 Hou, Ting,Li, Yixue,Sun, Yidi,et al. The Safety of Ovarian Preservation in Stage I Endometrial Endometrioid Adenocarcinoma Based on Propensity Score Matching[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2017,20(7):647-655.
APA Hou, Ting.,Li, Yixue.,Sun, Yidi.,Li, Junyi.,Wang, Zhen.,...&,.(2017).The Safety of Ovarian Preservation in Stage I Endometrial Endometrioid Adenocarcinoma Based on Propensity Score Matching.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,20(7),647-655.
MLA Hou, Ting,et al."The Safety of Ovarian Preservation in Stage I Endometrial Endometrioid Adenocarcinoma Based on Propensity Score Matching".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 20.7(2017):647-655.

入库方式： OAI收割

来源：上海营养与健康研究所

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