Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis
文献类型：期刊论文
| 作者 | He, Tao2; Zhang, Chen2; Liu, Denghui2; Xu, Weidong2; Huan, Yan1; Zhang, Xiaoling1; Zhang, Xiaoling3; Cheng, Chao4; , |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:57页码:96993-97008 |
| 关键词 | interleukin-17 mesenchymal stem cells polarization new bone formation ankylosing spondylitis |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.20823 |
| 文献子类 | Article |
| 英文摘要 | It's still unknown how over-hyperplasia of tissue such like new bone formation (NBF) developed in ankylosing spondylitis (AS). We found low level of IL-17A promoted TLR4+MSC1 polarization with suppressed osteogenic differentiation through JAK2/STAT3 pathway, while high level of IL-17A promoted TLR3+MSC2 polarization with enhanced osteogenic differentiation through WNT10b/RUNX2 pathway. Furthermore, both proteoglycan-induced spondylitis (PGISp) mouse model and AS patients without NBF showed MSC1 polarization, up-regulated JAK2/STAT3 pathway and high level of IL-17A (peripherally, but not locally), but those with NBF showed MSC2 polarization, up-regulated WNT10b/RUNX2 pathway and high expression of IL-17A at local site. Results showed NBF of AS was induced by MSC2 polarization that was promoted by high level of IL-17A, and may be treated by suppressing local MSC2 polarization. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; BETA-CATENIN ; SPONDYLOARTHRITIS ; DISEASE ; GROWTH ; IMMUNOSUPPRESSION ; REGENERATION ; MACROPHAGES ; DAMAGE ; DSRNA |
| 语种 | 英语 |
| WOS记录号 | WOS:000419395000053 |
| 出版者 | IMPACT JOURNALS LLC |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/662]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci,Sch Med, Shanghai, Peoples R China; 2.Second Mil Med Univ, Changhai Hosp, Dept Joint Surg & Sports Med, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Xin Hua Hosp, Sch Med, Dept Orthoped Surg, Shanghai, Peoples R China; 4.Second Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | He, Tao,Zhang, Chen,Liu, Denghui,et al. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis[J]. ONCOTARGET,2017,8(57):96993-97008. |
| APA | He, Tao.,Zhang, Chen.,Liu, Denghui.,Xu, Weidong.,Huan, Yan.,...&,.(2017).Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis.ONCOTARGET,8(57),96993-97008. |
| MLA | He, Tao,et al."Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis".ONCOTARGET 8.57(2017):96993-97008. |
入库方式： OAI收割
来源：上海营养与健康研究所
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