Preexisting endothelial cells mediate cardiac neovascularization after injury
文献类型：期刊论文
| 作者 | He, Lingjuan4,5; Huang, Xiuzhen4,5; Li, Yi4,5; Wang, Yue4,5; Li, Yan4,5; Pu, Wenjuan4,5; Liu, Qiaozhen4,5; Zhang, Hui4,5; Tian, Xueying4,5; Zhao, Huan4,5 |
| 刊名 | JOURNAL OF CLINICAL INVESTIGATION
 |
| 出版日期 | 2017 |
| 卷号 | 127期号:8页码:2968-2981 |
| ISSN号 | 0021-9738 |
| 关键词 | VLDLR PPAR FGF21 ATF4 ER stress |
| DOI | 10.1172/JCI93868 |
| 文献子类 | Article |
| 英文摘要 | The mechanisms that promote the generation of new coronary vasculature during cardiac homeostasis and after injury remain a fundamental and clinically important area of study in the cardiovascular field. Recently, it was reported that mesenchymal-to-endothelial transition (MEndoT) contributes to substantial numbers of coronary endothelial cells after myocardial infarction. Therefore, the MEndoT has been proposed as a paradigm mediating neovascularization and is considered a promising therapeutic target in cardiac regeneration. Here, we show that preexisting endothelial cells mainly beget new coronary vessels in the adult mouse heart, with essentially no contribution from other cell sources through cell-lineage transdifferentiation. Genetic-lineage tracing revealed that cardiac fibroblasts expand substantially after injury, but do not contribute to the formation of new coronary blood vessels, indicating no contribution of MEndoT to neovascularization. Moreover, genetic-lineage tracing with a pulse-chase labeling strategy also showed that essentially all new coronary vessels in the injured heart are derived from preexisting endothelial cells, but not from other cell lineages. These data indicate that therapeutic strategies for inducing neovascularization should not be based on targeting presumptive lineage transdifferentiation such as MEndoT. Instead, preexisting endothelial cells appear more likely to be the therapeutic target for promoting neovascularization and driving heart regeneration after injury. |
| 学科主题 | Research & Experimental Medicine |
| WOS关键词 | C-KIT(+) CELLS ; CORONARY-ARTERIES ; PROGENITOR CELLS ; STEM-CELLS ; HEART ; FIBROBLASTS ; ANGIOGENESIS ; CRE ; CARDIOMYOCYTES ; CONTRIBUTES |
| 语种 | 英语 |
| 出版者 | AMER SOC CLINICAL INVESTIGATION INC |
| WOS记录号 | WOS:000406679500012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/663]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China, 2.Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China; 3.Jinan Univ, Inst Aging & Regenerat Med, Minist Educ, Key Lab Regenerat Med, Guangzhou, Guangdong, Peoples R China; 4.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,CAS, Shanghai, Peoples R China; 5.Univ Chinese Acad Sci, CAS, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China; 6.Cincinnati Childrens Hosp Med Ctr, Dept Pediat & Mol Cardiovasc Biol, Cincinnati, OH 45229 USA; 7.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing, Peoples R China; 8.Peking Union Med Coll, Beijing, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Flow Cytometry Core Facil, Shanghai, Peoples R China; 10.AstraZeneca, Cardiovasc & Metab Dis Innovat Med & Early Clin D, Molndal, Sweden; |
| 推荐引用方式 GB/T 7714 | He, Lingjuan,Huang, Xiuzhen,Li, Yi,et al. Preexisting endothelial cells mediate cardiac neovascularization after injury[J]. JOURNAL OF CLINICAL INVESTIGATION,2017,127(8):2968-2981. |
| APA | He, Lingjuan.,Huang, Xiuzhen.,Li, Yi.,Wang, Yue.,Li, Yan.,...&,.(2017).Preexisting endothelial cells mediate cardiac neovascularization after injury.JOURNAL OF CLINICAL INVESTIGATION,127(8),2968-2981. |
| MLA | He, Lingjuan,et al."Preexisting endothelial cells mediate cardiac neovascularization after injury".JOURNAL OF CLINICAL INVESTIGATION 127.8(2017):2968-2981. |
入库方式： OAI收割
来源：上海营养与健康研究所
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