Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
文献类型：期刊论文
| 作者 | Zhang, Yunfang1,2,3; Li, Xin2; Liu, Yusheng2; Zhang, Liwen2,3; Qu, Yongcun2,3; Qian, Jingjing2,3; Cao, Zhonghong2; Lei, Xiaohua2; Cao, Yujing2; Li, Lei2 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 20期号:5页码:535-+ |
| ISSN号 | 1465-7392 |
| DOI | 10.1038/s41556-018-0087-2 |
| 文献子类 | Article |
| 英文摘要 | The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional paternal information aside from solely providing the DNA(1). Increasing evidence now suggests that sperm small non-coding RNAs (sncRNAs) can mediate intergenerational transmission of paternally acquired phenotypes, including mental stress(2,3) and metabolic disorders(4-6). How sperm sncRNAs encode paternal information remains unclear, but the mechanism may involve RNA modifications. Here we show that deletion of a mouse tRNA methyltransferase, DNMT2, abolished sperm sncRNA-mediated transmission of high-fat-diet-induced metabolic disorders to offspring. Dnmt2 deletion prevented the elevation of RNA modifications (m(5)C, m(2)G) in sperm 30-40 nt RNA fractions that are induced by a high-fat diet. Also, Dnmt2 deletion altered the sperm small RNA expression profile, including levels of tRNA-derived small RNAs and rRNA-derived small RNAs, which might be essential in composing a sperm RNA 'coding signature' that is needed for paternal epigenetic memory. Finally, we show that Dnmt2-mediated m(5)C contributes to the secondary structure and biological properties of sncRNAs, implicating sperm RNA modifications as an additional layer of paternal hereditary information. |
| 学科主题 | Cell Biology |
| WOS关键词 | TRANSGENERATIONAL INHERITANCE ; EPIGENETIC INHERITANCE ; REGULATES TRANSLATION ; PROTEIN-SYNTHESIS ; DNA ; METHYLATION ; SEQUENCE ; BIOGENESIS ; MAMMALS ; STRESS |
| 语种 | 英语 |
| WOS记录号 | WOS:000431064700010 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/665]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Nevada, Dept Physiol & Cell Biol, Reno Sch Med, Reno, NV 89557 USA; 2.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Beijing, Peoples R China; 4.German Canc Res Ctr, Div Epigenet, DKFZ ZMBH Alliance, Heidelberg, Germany; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Ctr Excellence Mol Cell Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China; 6.Shandong Univ Technol, Coll Life Sci, Zibo, Peoples R China; 7.Univ Nevada, Reno Sch Med, Nevada Prote Ctr, Reno, NV 89557 USA, |
| 推荐引用方式 GB/T 7714 | Zhang, Yunfang,Li, Xin,Liu, Yusheng,et al. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs[J]. NATURE CELL BIOLOGY,2018,20(5):535-+. |
| APA | Zhang, Yunfang.,Li, Xin.,Liu, Yusheng.,Zhang, Liwen.,Qu, Yongcun.,...&,.(2018).Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs.NATURE CELL BIOLOGY,20(5),535-+. |
| MLA | Zhang, Yunfang,et al."Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs".NATURE CELL BIOLOGY 20.5(2018):535-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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