Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice
文献类型：期刊论文
| 作者 | Ba, Qian1,2; Li, Mian1; Chen, Peizhan1; Huang, Chao1; Lu, Lijun1; Li, Jingquan1,2; Chu, Ruiai1,2; Xie, Dong1,2; Song, Haiyun1,2; Ying, Hao1,2 |
| 刊名 | ENVIRONMENTAL HEALTH PERSPECTIVES
 |
| 出版日期 | 2017 |
| 卷号 | 125期号:3页码:437-446 |
| 关键词 | Nucleotides Meta-analysis Growth Infant formula |
| ISSN号 | 0091-6765 |
| DOI | 10.1289/EHP360 |
| 文献子类 | Article |
| 英文摘要 | BACKGROUND: Environmental cadmium, with a high average dietary intake, is a severe public health risk. However, the long-term health implications of environmental exposure to cadmium in different life stages remain unclear. OBJECTIVES: We investigated the effects of early exposure to cadmium, at an environmentally relevant dosage, on adult metabolism and the mechanism of action. METHODS: We established mouse models with low-dose cadmium (LDC) exposure in early life to examine the long-term metabolic consequences. Intestinal flora measurement by 16S rDNA sequencing, microbial ecological analyses, and fecal microbiota transplant was conducted to explore the potential underlying mechanisms. RESULTS: Early LDC exposure (100 nM) led to fat accumulation in adult male mice. Hepatic genes profiling revealed that fatty acid and lipid metabolic processes were elevated. Gut microbiota were perturbed by LDC to cause diversity reduction and compositional alteration. Time-series studies indicated that the gut flora at early-life stages, especially at 8 weeks, were vulnerable to LDC and that an alteration during this period could contribute to the adult adiposity, even if the microbiota recovered later. The importance of intestinal bacteria in LDC-induced fat accumulation was further confirmed through microbiota transplantation and removal experiments. Moreover, the metabolic effects of LDC were observed only in male, but not female, mice. CONCLUSIONS: An environmental dose of cadmium at early stages of life causes gut microbiota alterations, accelerates hepatic lipid metabolism, and leads to life-long metabolic consequences in a sex-dependent manner. These findings provide a better understanding of the health risk of cadmium in the environment. |
| 学科主题 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
| WOS关键词 | DIETARY-INTAKE ; PROSPECTIVE COHORT ; OXIDATIVE STRESS ; WOMENS HEALTH ; DISEASE ; MECHANISMS ; POPULATION ; METALS ; RISK ; CONSEQUENCES |
| 语种 | 英语 |
| WOS记录号 | WOS:000395714400026 |
| 出版者 | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/666]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Key Lab food safety Res, Shanghai, Peoples R China; 2.Minist Hlth, Key Lab food safety risk Assessment, 7 Panjiayuan Nanli, Beijing 100021, Peoples R China; 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 4.Chinese Acad Sci, Shanghai Clin Ctr, Xuhui Cent Hosp, Shanghai, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Ba, Qian,Li, Mian,Chen, Peizhan,et al. Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(3):437-446. |
| APA | Ba, Qian.,Li, Mian.,Chen, Peizhan.,Huang, Chao.,Lu, Lijun.,...&,.(2017).Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice.ENVIRONMENTAL HEALTH PERSPECTIVES,125(3),437-446. |
| MLA | Ba, Qian,et al."Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice".ENVIRONMENTAL HEALTH PERSPECTIVES 125.3(2017):437-446. |
入库方式： OAI收割
来源：上海营养与健康研究所
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