Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation
文献类型：期刊论文
| 作者 | Liu, Xin5; Zhang, Yuannyu5; Ni, Min5; Cao, Hui5; Signer, Robert A. J.5; Li, Dan5; Gu, Zhimin5; Hu, Zeping5; Dickerson, Kathryn E.5; DeBerardinis, Ralph J.5 |
| 刊名 | NATURE CELL BIOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 19期号:6页码:626-+ |
| 关键词 | Caenorhabditis elegans nutrition axenic media liposomes feeding |
| ISSN号 | 1465-7392 |
| DOI | 10.1038/ncb3527 |
| 文献子类 | Article |
| 英文摘要 | Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here we compare the genome-scale proteomic and transcriptomic changes in human primary haematopoietic stem/progenitor cells and erythroid progenitors, and uncover pathways related to mitochondrial biogenesis enhanced through post-transcriptional regulation. Mitochondrial factors including TFAM and PHB2 are selectively regulated through protein translation during erythroid specification. Depletion of TFAM in erythroid cells alters intracellular metabolism, leading to elevated histone acetylation, deregulated gene expression, and defective mitochondria and erythropoiesis. Mechanistically, mTORC1 signalling is enhanced to promote translation of mitochondria-associated transcripts through TOP-like motifs. Genetic and pharmacological perturbation of mitochondria or mTORC1 specifically impairs erythropoiesis in vitro and in vivo. Our studies support a mechanism for post-transcriptional control of erythroid mitochondria and may have direct relevance to haematologic defects associated with mitochondrial diseases and ageing. |
| 学科主题 | Cell Biology |
| WOS关键词 | HEMATOPOIETIC STEM-CELLS ; DIAMOND-BLACKFAN ANEMIA ; L-LEUCINE IMPROVES ; MASS-SPECTROMETRY ; GENE-EXPRESSION ; MESSENGER-RNAS ; MOUSE MODEL ; MTOR ; SEQ ; TRANSCRIPTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000402525200011 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/667]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif San Diego, Dept Med, Moores Canc Ctr, Div Regenerat Med, La Jolla, CA 92093 USA; 2.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Key Lab Carcinogenesis & Canc Invas,Minister Educ, Shanghai 200032, Peoples R China; 3.Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA; 4.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China, 5.Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Res Inst, Childrens Med Ctr, Dallas, TX 75390 USA; 6.Chinese Acad Sci, Key Lab Computat Biol, Collaborat Innovat Ctr Genet & Dev Biol, CAS MPG Partner Inst Computat Biol,Shanghai Inst, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Xin,Zhang, Yuannyu,Ni, Min,et al. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation[J]. NATURE CELL BIOLOGY,2017,19(6):626-+. |
| APA | Liu, Xin.,Zhang, Yuannyu.,Ni, Min.,Cao, Hui.,Signer, Robert A. J..,...&,.(2017).Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.NATURE CELL BIOLOGY,19(6),626-+. |
| MLA | Liu, Xin,et al."Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation".NATURE CELL BIOLOGY 19.6(2017):626-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
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