Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells
文献类型：期刊论文
| 作者 | Yang, Yunxia; Yu, Song; Tan, Yanglan; Liu, Na; Wu, Aibo; , |
| 刊名 | TOXINS
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:3页码:96 |
| 关键词 | deoxynivalenol mycotoxins human gastric epithelial cell cytotoxicity combination index |
| ISSN号 | 2072-6651 |
| DOI | 10.3390/toxins9030096 |
| 文献子类 | Article |
| 英文摘要 | Mycotoxin contamination is a significant health concern for human beings, but health risk assessments are usually based on one single mycotoxin, which might neglect the additive or competitive interactions between co-occurring mycotoxins. In this study, we assessed the individual or combined toxicological effects to multiple deoxynivalenol-family mycotoxins, namely deoxynivalenol (DON), Nivalenol (NIV), and their acetyl derivatives of 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), deoxynivalenol-3-glucoside (D3G), and Fusarenon-X (FX) based on the human gastric epithelial (GES-1) cells. GES-1 cells were treated at different concentrations over 24 h and cell viability was measured by a cell counting kit (CCK8). The results show that D3G has no toxicity and 3-ADON is less potent in reducing cell viability compared to DON, whereas 15-ADON and FX appear to be slightly less potent than their parent compounds of DON and NIV on GES-1 cells. In general, the toxic ability of individual mycotoxins was shown as 3-ADON << 15-ADON < DON < FX < NIV, in an increasing order. All mixtures caused a dose-dependent decline of cell viability and the interactions analysis of binary combinations were assessed using the combination index (CI)-isobologram method. For the interaction types of mycotoxins mixtures, the synergistic cytotoxicity of DON + 15-ADON, DON + NIV, and DON + FX at low and/or moderate inhibitory concentration levels (IC10-IC70, IC10-IC80, and IC10-IC40, respectively) were observed. FX + NIV resulted in almost completely synergistic cytotoxicity, whereas 15-ADON + NIV and 15-ADON + FX presented almost entirely antagonistic cytotoxicity on the GES-1 cell model. These results suggest that the simultaneous presence of low-dose type B trichothecenes in dietary food may be more or less toxic than the prediction based on individual mycotoxins. |
| 学科主题 | Food Science & Technology ; Toxicology |
| WOS关键词 | MASKED MYCOTOXINS ; DRUG-COMBINATION ; B TRICHOTHECENES ; RISK ASSESSMENT ; HUMAN EXPOSURE ; FOOD SAFETY ; DERIVATIVES ; TOXICITY ; IMPACTS ; MAIZE |
| 语种 | 英语 |
| WOS记录号 | WOS:000398725400023 |
| 出版者 | MDPI AG |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/670]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Univ Chinese Acad Sci, SIBS UGENT SJTU Joint Lab Mycotoxin Res, Key Lab food safety Res, Inst Nutr Sci,Shanghai Inst Biol Sci,Chinese Acad, Shanghai 200000, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Yang, Yunxia,Yu, Song,Tan, Yanglan,et al. Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells[J]. TOXINS,2017,9(3):96. |
| APA | Yang, Yunxia,Yu, Song,Tan, Yanglan,Liu, Na,Wu, Aibo,&,.(2017).Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells.TOXINS,9(3),96. |
| MLA | Yang, Yunxia,et al."Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells".TOXINS 9.3(2017):96. |
入库方式： OAI收割
来源：上海营养与健康研究所
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