Identification of Immediate Early Genes in the Nervous System of Snail Helix lucorum
文献类型：期刊论文
| 作者 | Xu, Chuan2; Li, Qian2; Jiang, Xi2; Petrova, Marina2; Efimova, Olga1; Koshkareva, Kira1; Khaitovich, Philipp1; Vinarskaya, Alia K.3; Kolosov, Peter3; Aseyev, Nikolay3 |
| 刊名 | ENEURO
 |
| 出版日期 | 2019 |
| 卷号 | 6期号:3页码:e0416-18.2019 |
| ISSN号 | 0022-1007 |
| 关键词 | snail immediate early genes Helix lucorum nervous system |
| DOI | 10.1523/ENEURO.0416-18.2019 |
| 文献子类 | Article |
| 英文摘要 | Immediate early genes (IEGs) are useful markers of neuronal activation and essential components of neuronal response. While studies of gastropods have provided many insights into the basic learning and memory mechanisms, the genome-wide assessment of IEGs has been mainly restricted to vertebrates. In this study, we identified IEGs in the terrestrial snail Helix lucorum. In the absence of the genome, we conducted de novo transcriptome assembly using reads with short and intermediate lengths cumulatively covering more than 98 billion nucleotides. Based on this assembly, we identified 37 proteins corresponding to contigs differentially expressed (DE) in either the parietal ganglia (PaG) or two giant interneurons located within the PaG of the snail in response to the neuronal stimulation. These proteins included homologues of well-known mammalian IEGs, such as c-jun/jund, C/EBP, c-fos/fosl2, and Egr1, as well as homologues of genes not yet implicated in the neuronal response. |
| 学科主题 | Immunology ; Research & Experimental Medicine |
| WOS关键词 | LONG-TERM FACILITATION ; TRANSCRIPTION FACTOR ; TERRESTRIAL SNAIL ; C-FOS ; NEURONAL-ACTIVITY ; EXPRESSION ; RNA ; GENOME ; CONSOLIDATION ; PROTEIN |
| 语种 | 英语 |
| CSCD记录号 | CSCD:31053606 |
| 出版者 | SOC NEUROSCIENCE |
| WOS记录号 | WOS:000473806900024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/672]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Skolkovo Inst Sci & Technol, Moscow 143026, Russia; 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Computat Biol,Max Planck Gesell Partn, Shanghai 200031, Peoples R China; 3.Inst Higher Nervous Act & Neurophysiol, Moscow 117485, Russia; 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Gesell Partner Inst Computat Biol, Comparat Biol Lab, Shanghai 200031, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xu, Chuan,Li, Qian,Jiang, Xi,et al. Identification of Immediate Early Genes in the Nervous System of Snail Helix lucorum[J]. ENEURO,2019,6(3):e0416-18.2019. |
| APA | Xu, Chuan.,Li, Qian.,Jiang, Xi.,Petrova, Marina.,Efimova, Olga.,...&,.(2019).Identification of Immediate Early Genes in the Nervous System of Snail Helix lucorum.ENEURO,6(3),e0416-18.2019. |
| MLA | Xu, Chuan,et al."Identification of Immediate Early Genes in the Nervous System of Snail Helix lucorum".ENEURO 6.3(2019):e0416-18.2019. |
入库方式： OAI收割
来源：上海营养与健康研究所
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