Identification of gene expression signatures across different types of neural stem cells with the Monte-Carlo feature selection method
文献类型：期刊论文
| 作者 | Chen, Lei1,5; Li, JiaRui5; Wang, ShaoPeng5; Cai, Yu-Dong5; Zhang, Yu-Hang4; Huang, Tao4; Kong, Xiangyin4; Feng, KaiYan3; Zhang, YunHua2; , |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 119期号:4页码:3394-3403 |
| 关键词 | gene expression pattern Monte-Carlo feature selection method neural stem cell |
| ISSN号 | 0730-2312 |
| DOI | 10.1002/jcb.26507 |
| 文献子类 | Article |
| 英文摘要 | Adult neural stem cells (NSCs) are a group of multi-potent, self-renewing progenitor cells that contribute to the generation of new neurons and oligodendrocytes. Three subtypes of NSCs can be isolated based on the stages of the NSC lineage, including quiescent neural stem cells (qNSCs), activated neural stem cells (aNSCs) and neural progenitor cells (NPCs). Although it is widely accepted that these three groups of NSCs play different roles in the development of the nervous system, their molecular signatures are poorly understood. In this study, we applied the Monte-Carlo Feature Selection (MCFS) method to identify the gene expression signatures, which can yield a Matthews correlation coefficient (MCC) value of 0.918 with a support vector machine evaluated by ten-fold cross-validation. In addition, some classification rules yielded by the MCFS program for distinguishing above three subtypes were reported. Our results not only demonstrate a high classification capacity and subtype-specific gene expression patterns but also quantitatively reflect the pattern of the gene expression levels across the NSC lineage, providing insight into deciphering the molecular basis of NSC differentiation. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | SERINE-PROTEASE HTRA1 ; GROWTH-FACTOR-I ; ADULT NEUROGENESIS ; PROGENITOR CELLS ; NONCODING RNAS ; BRAIN ; MOUSE ; TRANSCRIPTOME ; PURIFICATION ; CLUSTERIN |
| 语种 | 英语 |
| WOS记录号 | WOS:000426187500037 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/678]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Maritime Univ, Coll Informat Engn, Shanghai, Peoples R China; 2.Anhui Agr Univ, Sch Resources & Environm, Anhui Prov Key Lab Farmland Ecol Conversat & Poll, Hefei, Anhui, Peoples R China, 3.Guangdong AIB Polytech, Dept Comp Sci, Guangzhou, Guangdong, Peoples R China; 4.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; 5.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Lei,Li, JiaRui,Wang, ShaoPeng,et al. Identification of gene expression signatures across different types of neural stem cells with the Monte-Carlo feature selection method[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2018,119(4):3394-3403. |
| APA | Chen, Lei.,Li, JiaRui.,Wang, ShaoPeng.,Cai, Yu-Dong.,Zhang, Yu-Hang.,...&,.(2018).Identification of gene expression signatures across different types of neural stem cells with the Monte-Carlo feature selection method.JOURNAL OF CELLULAR BIOCHEMISTRY,119(4),3394-3403. |
| MLA | Chen, Lei,et al."Identification of gene expression signatures across different types of neural stem cells with the Monte-Carlo feature selection method".JOURNAL OF CELLULAR BIOCHEMISTRY 119.4(2018):3394-3403. |
入库方式： OAI收割
来源：上海营养与健康研究所
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