LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment
文献类型：期刊论文
| 作者 | Song, Lele2,3,4; Guo, Jingyu3,4; Chang, Renxu3,4; Zhan, Lixing4; Peng, Xiaobo2; Li, Jie2; Zhan, Xianbao2; Xu, Xiaorong1; , |
| 刊名 | CANCER SCIENCE
 |
| 出版日期 | 2018 |
| 卷号 | 109期号:5页码:1382-1392 |
| 关键词 | liver kinase B1 metformin pancreatic cancer Snail ubiquitination |
| ISSN号 | 1349-7006 |
| DOI | 10.1111/cas.13591 |
| 文献子类 | Article |
| 英文摘要 | Metastasis to distant organs is a particularly ominous feature of malignant cancer. LKB1 (also known as STK11) has been identified as a tumor suppressor in several types of cancers. Here, we show that LKB1 is at low levels and is negatively associated with poor clinical outcomes in pancreatic cancer (PC). LKB1 is inversely correlated with Snail protein in PC, in which the loss of LKB1 facilitates metastasis through elevating Snail protein level. Furthermore, LKB1 boosts Snail's interaction with E3 ligase FBXL14, leading to increasing ubiquitin-mediated Snail degradation. Notably, metformin could increase Snail protein ubiquitination via augmenting the location of LKB1 at cytoplasm as well as increasing LKB1 expression. Altogether, our data established that LKB1 impedes invasion and metastasis by decreasing the Snail protein level in PC. Targeting the LKB1/FBXL14/Snail axis may represent a promising therapeutic strategy and metformin might be beneficial for PC therapy through activating the LKB1-mediated Snail ubiquitination pathway. |
| 学科主题 | Oncology |
| WOS关键词 | BOX PROTEIN PPA ; TUMOR-SUPPRESSOR ; EXPRESSION ; GROWTH ; PATHWAY ; CELLS ; GENE ; CARCINOMA ; BIOMARKER ; POLARITY |
| 语种 | 英语 |
| WOS记录号 | WOS:000434071400010 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/679]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Tongji Univ, Shanghai Peoples Hosp 10, Dept Gastroenterol, Shanghai, Peoples R China, 2.Second Mil Med Univ, Changhai Hosp, Shanghai, Peoples R China; 3.Univ Chinese Acad Sci, Shanghai, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Song, Lele,Guo, Jingyu,Chang, Renxu,et al. LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment[J]. CANCER SCIENCE,2018,109(5):1382-1392. |
| APA | Song, Lele.,Guo, Jingyu.,Chang, Renxu.,Zhan, Lixing.,Peng, Xiaobo.,...&,.(2018).LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment.CANCER SCIENCE,109(5),1382-1392. |
| MLA | Song, Lele,et al."LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment".CANCER SCIENCE 109.5(2018):1382-1392. |
入库方式： OAI收割
来源：上海营养与健康研究所
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