Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells
文献类型：期刊论文
| 作者 | Wang, Guan2,5; Cao, Kai2,5; Liu, Keli2,5; Xue, Yueqing2,5; Li, Fengying2,5; Han, Yanyan2,5; Wang, Ying2,5; Shi, Yufang2,5; Roberts, Arthur, I1; Rabson, Arnold B.1 |
| 刊名 | CELL DEATH AND DIFFERENTIATION
 |
| 出版日期 | 2018 |
| 卷号 | 25期号:7页码:1209-1223 |
| ISSN号 | 1350-9047 |
| DOI | 10.1038/s41418-017-0006-2 |
| 文献子类 | Article |
| 英文摘要 | Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6). However, little is known about the necessity for both of these key immunosuppressive factors. Here we employed the mouse lipopolysaccharide (LPS)-induced acute lung injury (ALI) model, and found that IDO is necessary to achieve the effect of human umbilical cord-derived MSC (hUC-MSC)-based treatment on ALI. Notably, when IDO was deleted or inhibited, the expression of TSG-6 was decreased. This specific IDO-mediated regulation of TSG-6 expression was found to be exerted through its metabolite, kynurenic acid (KYNA), as inhibition of KYNA production led to decreased TSG-6 expression. Importantly, KYNA pretreatment of human MSCs enhanced their therapeutic effect on ALI. Mechanistically, KYNA activates aryl hydrocarbon receptor (AhR), which directly binds to the TSG-6 promoter to enhance TSG-6 expression. Therefore, our study has uncovered a novel link between IDO and TSG-6, and demonstrates that a metabolite of IDO controls the TSG-6-mediated anti-inflammatory therapeutic effects of human MSCs. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | RESPIRATORY-DISTRESS-SYNDROME ; ACUTE LUNG INJURY ; ARYL-HYDROCARBON RECEPTOR ; ANTIINFLAMMATORY PROTEIN TSG-6 ; REGULATORY T-CELLS ; INDOLEAMINE 2,3-DIOXYGENASE ; DENDRITIC CELLS ; MEDIATED IMMUNOSUPPRESSION ; PROLIFERATION ; INFLAMMATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000437809700004 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/682]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Rutgers State Univ, Robert Wood Johnson Med Sch, Child Hlth Inst, 89 French St, Piscataway, NJ 08901 USA; 2.Univ Chinese Acad Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 3.Soochow Univ, Inst Translat Med, Jiangsu Prov & Chinese Minist Sci & Technol, Key Lab Stem Cells & Biomed Mat, 199 Renai Rd, Suzhou 215123, Peoples R China, 4.Soochow Univ, Affiliated Hosp 1, 199 Renai Rd, Suzhou 215123, Peoples R China; 5.Shanghai Jiao Tong Univ Med, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol,Inst Hlth Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Guan,Cao, Kai,Liu, Keli,et al. Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells[J]. CELL DEATH AND DIFFERENTIATION,2018,25(7):1209-1223. |
| APA | Wang, Guan.,Cao, Kai.,Liu, Keli.,Xue, Yueqing.,Li, Fengying.,...&,.(2018).Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells.CELL DEATH AND DIFFERENTIATION,25(7),1209-1223. |
| MLA | Wang, Guan,et al."Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells".CELL DEATH AND DIFFERENTIATION 25.7(2018):1209-1223. |
入库方式： OAI收割
来源：上海营养与健康研究所
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