Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome
文献类型：期刊论文
| 作者 | Chen, Weiyan3; Teschendorff, Andrew E.3; Morabito, Samuel J.1; Kessenbrock, Kai1; Enver, Tariq4; Meyer, Kerstin B.2; , |
| 刊名 | COMMUNICATIONS BIOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 2期号:-页码:306 |
| 关键词 | titanium dioxide nanoparticles epithelial-mesenchymal transition TGF beta signaling colitis tissue regeneration |
| ISSN号 | 1944-8244 |
| DOI | 10.1038/s42003-019-0554-8 |
| 文献子类 | Article |
| 英文摘要 | Adult stem-cells may serve as the cell-of-origin for cancer, yet their unbiased identification in single cell RNA sequencing data is challenging due to the high dropout rate. In the case of breast, the existence of a bipotent stem-like state is also controversial. Here we apply a marker-free algorithm to scRNA-Seq data from the human mammary epithelium, revealing a high-potency cell-state enriched for an independent mammary stem-cell expression module. We validate this stem-like state in independent scRNA-Seq data. Our algorithm further predicts that the stem-like state is bipotent, a prediction we are able to validate using FACS sorted bulk expression data. The bipotent stem-like state correlates with clinical outcome in basal breast cancer and is characterized by overexpression of YBX1 and ENO1, two modulators of basal breast cancer risk. This study illustrates the power of a marker-free computational framework to identify a novel bipotent stem-like state in the mammary epithelium. |
| 学科主题 | Science & Technology - Other Topics ; Materials Science |
| WOS关键词 | EXPRESSION ; IDENTIFICATION ; HETEROGENEITY ; PROGENITORS ; REGULATORS ; ENTROPY ; ATLAS ; MAPS |
| 语种 | 英语 |
| WOS记录号 | WOS:000481512900003 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/687]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif Irvine, Chao Family Comprehens Canc Ctr, 839 Hlth Sci Rd,Sprague Hall 114 Irvine, Irvine, CA 92697 USA; 2.Wellcome Sanger Inst, Cambridge CB10 1SA, England, 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol,CAS Key Lab Co, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; 4.UCL, UCL Canc Inst, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England; |
| 推荐引用方式 GB/T 7714 | Chen, Weiyan,Teschendorff, Andrew E.,Morabito, Samuel J.,et al. Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome[J]. COMMUNICATIONS BIOLOGY,2019,2(-):306. |
| APA | Chen, Weiyan.,Teschendorff, Andrew E..,Morabito, Samuel J..,Kessenbrock, Kai.,Enver, Tariq.,...&,.(2019).Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome.COMMUNICATIONS BIOLOGY,2(-),306. |
| MLA | Chen, Weiyan,et al."Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome".COMMUNICATIONS BIOLOGY 2.-(2019):306. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。