Lipidome Evolution in Mammalian Tissues
文献类型：期刊论文
| 作者 | Khrameeva, Ekaterina6,7; Kurochkin, Ilia6; Khaitovich, Philipp6; Bozek, Katarzyna1; Giavalisco, Patrick2,5; Khaitovich, Philipp3,4; , |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2018 |
| 卷号 | 35期号:8页码:1947-1957 |
| 关键词 | humans brain lipidome molecular evolution mass spectrometry |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msy097 |
| 文献子类 | Article |
| 英文摘要 | Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders. |
| 学科主题 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| WOS关键词 | MOLECULAR EVOLUTION ; ADAPTIVE EVOLUTION ; ALZHEIMERS-DISEASE ; ENDOCANNABINOIDS ; PATHOGENESIS ; ORGANIZATION ; METABOLOME ; DIVERGENCE ; DISORDERS ; LONGEVITY |
| 语种 | 英语 |
| WOS记录号 | WOS:000441143000009 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/688]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Grad Univ, Okinawa Inst Sci & Technol, Biol Phys Theory Unit, Onna Son, Okinawa, Japan; 2.Max Planck Inst Mol Plant Physiol, Potsdam, Germany; 3.Max Planck Inst Evolutionary Anthropol, Leipzig, Germany; 4.CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai, Peoples R China; 5.Max Planck Inst Biol Ageing, Cologne, Germany, 6.Skolkovo Inst Sci & Technol, Ctr Data Intens Biomed & Biotechnol, Moscow, Russia; 7.Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, Moscow, Russia; |
| 推荐引用方式 GB/T 7714 | Khrameeva, Ekaterina,Kurochkin, Ilia,Khaitovich, Philipp,et al. Lipidome Evolution in Mammalian Tissues[J]. MOLECULAR BIOLOGY AND EVOLUTION,2018,35(8):1947-1957. |
| APA | Khrameeva, Ekaterina.,Kurochkin, Ilia.,Khaitovich, Philipp.,Bozek, Katarzyna.,Giavalisco, Patrick.,...&,.(2018).Lipidome Evolution in Mammalian Tissues.MOLECULAR BIOLOGY AND EVOLUTION,35(8),1947-1957. |
| MLA | Khrameeva, Ekaterina,et al."Lipidome Evolution in Mammalian Tissues".MOLECULAR BIOLOGY AND EVOLUTION 35.8(2018):1947-1957. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。