Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis
文献类型：期刊论文
| 作者 | Huang, Mingjian1,2,3; Zhao, Jingyu1,2,3; Dai, Liming3; Zhang, Xiaoling1,2,3; Huang, Yan1,2; , |
| 刊名 | JOURNAL OF ORTHOPAEDIC TRANSLATION
 |
| 出版日期 | 2018 |
| 卷号 | 13期号:-页码:50-57 |
| 关键词 | biomarkers osteoarthritis urinary C-terminal telopeptide of type II collagen |
| ISSN号 | 2214-031X |
| DOI | 10.1016/j.jot.2017.06.005 |
| 文献子类 | Article |
| 英文摘要 | Objective: This study aims to discover that the urinary C-terminal telopeptide of type II collagen (uCTX-II) levels differ between osteoarthritis (OA) patients and healthy individuals (controls). According to this difference, we may conclude that uCTX-II can be a biomarker for OA diagnosis. Methods: We searched MEDLINE and EMBASE databases updated to 2014 to find literature on OA biomarkers. We retrieved the publications that met the required criterion. Literature quality was assessed according to the Newcastle-Ottawa Scale. Publication bias was assessed by Begg's test and Egger's test with the software STATA version 12.0. The weighted mean difference (WMD) was calculated, and the subgroup analysis was completed using STATA 12.0. Results: Six publications were included in our analysis. The WMD for OA patients versus the controls was 83.05, which was within the 95% confidence interval. For subgroup analysis, the WMD of patients with severe OA was 119.92, whereas that of patients with mild OA was 28.07. Conclusions: uCTX-II levels were higher in OA patients than in controls, subgroup analysis revealed that the uCTX-II levels rised with the OA severity, the heterogeneity originated from different levels of OA severity, These results showed that uCTX-II would be a promising clinical biomarker in OA diagnosis. (C) 2018 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society. |
| 学科主题 | Orthopedics |
| WOS关键词 | DESTRUCTIVE HIP OSTEOARTHRITIS ; BIOCHEMICAL MARKERS ; KNEE OSTEOARTHRITIS ; JOINT DAMAGE ; CARTILAGE ; FRAGMENTS ; DISEASE ; SERUM ; BONE |
| 语种 | 英语 |
| WOS记录号 | WOS:000429776100008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/691]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.SJTUSM, Shanghai 200031, Peoples R China, 2.Chinese Acad Sci, SIBS, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China; 3.SJTUSM, Xin Hua Hosp, Dept Orthoped Surg, Shanghai 200092, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Huang, Mingjian,Zhao, Jingyu,Dai, Liming,et al. Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2018,13(-):50-57. |
| APA | Huang, Mingjian,Zhao, Jingyu,Dai, Liming,Zhang, Xiaoling,Huang, Yan,&,.(2018).Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis.JOURNAL OF ORTHOPAEDIC TRANSLATION,13(-),50-57. |
| MLA | Huang, Mingjian,et al."Meta-analysis of urinary C-terminal telopeptide of type II collagen as a biomarker in osteoarthritis diagnosis".JOURNAL OF ORTHOPAEDIC TRANSLATION 13.-(2018):50-57. |
入库方式： OAI收割
来源：上海营养与健康研究所
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