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PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation

文献类型：期刊论文

作者Zhang, Huanhuan4,5; Han, Ruomei4,5; Hou, Yongfan5; You, Xue4,5; Huang, Meiqin5; Zhao, Zilong5; Wang, Zhenzhen5; Chen, Yan4,5; Ling, Zhi-Qiang3; Zhang, Fuyuan1,2
刊名CARCINOGENESIS
出版日期2018
卷号39期号:3页码:439-446
关键词Breast cancer AEP USP17 Deubiquitination ERK
ISSN号0143-3334
DOI10.1093/carcin/bgx143
文献子类Article
英文摘要Progestin and adipoQ receptor 4 (PAQR4) is a member of the PAQR family, and the members within this family are involved in the regulation of a number of biological processes including metabolism and cancer development. The potential function of PAQR4 in human cancers is unknown. Analysis of ONCOMINE database reveals that PAQR4 is highly expressed in human breast cancers. We confirmed this finding by analyzing 82 human breast cancers samples. PAQR4 mRNA level was significantly upregulated in human breast cancer samples compared with their corresponding para-cancerous histological normal tissues (P < 0.0001). The mRNA level of PAQR4 was negatively correlated with disease-free survival (P < 0.0001) and overall survival of the patients (P = 0.001). Knockdown of PAQR4 in human breast cancer cells SUM159 and MCF7 suppressed cell proliferation. In contrast, overexpression of PAQR4 in SUM159 cells enhanced cell proliferation and colony formation. In a tumor xenograft model, overexpression of PAQR4 promoted tumor growth of SUM159 cells in vivo, while PAQR4 knockdown suppressed the tumor growth. PAQR4 was able to negatively regulate cyclin-dependent kinases 4 (CDK4) protein level in the breast cancer cells. Knockdown of PAQR4 accelerated degradation of CDK4 together with upregulation of CDK4 polyubiquitination. On the other hand, overexpression of PAQR4 slowed down CDK4 protein degradation and reduced CDK4 polyubiquitination. Collectively, these data at the cellular, animal and human levels indicate that PAQR4 has a tumorigenic effect on human breast cancers, and such effect is associated with a modulatory activity of PAQR4 on protein degradation of CDK4.
学科主题Oncology
WOS关键词TUMOR-SUPPRESSOR ; CELL CARCINOMA ; IDENTIFICATION ; EXPRESSION ; PLAYS ; RKTG
语种英语
WOS记录号WOS:000427120100014
出版者OXFORD UNIV PRESS
版本出版稿
源URL[http://202.127.25.144/handle/331004/694]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai, Peoples R China,
2.Chinese Acad Sci, Shanghai Inst Organ Chem, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Bioorgan & Nat Prod Chem, Shanghai, Peoples R China;
3.Zhejiang Prov Canc Hosp, Zhejiang Canc Res Inst, Zhejiang Canc Ctr, Hangzhou, Zhejiang, Peoples R China;
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China;
5.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China;
推荐引用方式
GB/T 7714		 Zhang, Huanhuan,Han, Ruomei,Hou, Yongfan,et al. PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation[J]. CARCINOGENESIS,2018,39(3):439-446.
APA Zhang, Huanhuan.,Han, Ruomei.,Hou, Yongfan.,You, Xue.,Huang, Meiqin.,...&,.(2018).PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation.CARCINOGENESIS,39(3),439-446.
MLA Zhang, Huanhuan,et al."PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation".CARCINOGENESIS 39.3(2018):439-446.

入库方式： OAI收割

来源：上海营养与健康研究所

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