MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1
文献类型：期刊论文
| 作者 | Gong, Xiu-Feng1; Yu, An-Lu1; Wang, Chen-Long1; Chen, Guo-Qiang1; Zhao, Qian1; He, Ming1; Zhou, Ci-Xiang1; Tang, Jun3,4; He, Jian-Rong2; , |
| 刊名 | EXPERIMENTAL CELL RESEARCH
 |
| 出版日期 | 2018 |
| 卷号 | 362期号:2页码:378-385 |
| ISSN号 | 0014-4827 |
| 关键词 | miR-630 Breast cancer BMI1 Apoptosis |
| DOI | 10.1016/j.yexcr.2017.11.039 |
| 文献子类 | Article |
| 英文摘要 | MicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630. |
| 学科主题 | Oncology ; Cell Biology |
| WOS关键词 | DNA-DAMAGE RESPONSE ; CELL RENEWAL FACTOR ; SELF-RENEWAL ; MIR-630 ; CARCINOMA ; REPAIR ; UBIQUITYLATION ; PROLIFERATION ; METASTASIS ; EXPRESSION |
| 语种 | 英语 |
| 出版者 | ELSEVIER INC |
| WOS记录号 | WOS:000422702500016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/695]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.SJTU, SM, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis,Natl Minist, Shanghai 200025, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Dept Gen Surg, Rui Jin Hosp, Shanghai 200025, Peoples R China, 3.SJTU, SM, Shanghai, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gong, Xiu-Feng,Yu, An-Lu,Wang, Chen-Long,et al. MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1[J]. EXPERIMENTAL CELL RESEARCH,2018,362(2):378-385. |
| APA | Gong, Xiu-Feng.,Yu, An-Lu.,Wang, Chen-Long.,Chen, Guo-Qiang.,Zhao, Qian.,...&,.(2018).MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1.EXPERIMENTAL CELL RESEARCH,362(2),378-385. |
| MLA | Gong, Xiu-Feng,et al."MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1".EXPERIMENTAL CELL RESEARCH 362.2(2018):378-385. |
入库方式： OAI收割
来源：上海营养与健康研究所
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