Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases
文献类型：期刊论文
| 作者 | Chen, Xiaodong; Wang, Shijia; Cao, Wei; , |
| 刊名 | CELLULAR IMMUNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 326期号:-页码:8-14 |
| 关键词 | Mesenchymal stem cells neurodegenerative diseases immunomodulation microglia T cells |
| ISSN号 | 0008-8749 |
| DOI | 10.1016/j.cellimm.2017.06.006 |
| 文献子类 | Article |
| 英文摘要 | Dysfunction of immune responses has been identified to involve in the pathogenesis of various neurodegenerative diseases. Abnormal activation of glia cells and/or infiltration of peripheral adaptive immune cells always sustains neuroinflammation and the disease progression. Obviously, the regulation of neuroinflammation has become a potential therapeutic strategy against neurodegenerative diseases. Mesenchymal stem cells (MSCs) exhibit complex interactions with various immune cells including T cells, macrophages and especially resident glia cells in the central nervous system. In response to tissue injury signals, MSCs adopt specific phenotype to suppress or promote immune responses depending on the inflammatory microenvironment they reside. Therefore, manipulation of MSCs may hold great potentials to improve MSC-based therapy on neurodegenerative diseases. Here we review MSC-mediated immunomodulation in cell therapy of neurodegenerative diseases, providing fundamental information for guiding appropriate applications of MSCs in clinical settings. |
| 学科主题 | Cell Biology ; Immunology |
| WOS关键词 | AMYOTROPHIC-LATERAL-SCLEROSIS ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; ADAPTIVE IMMUNE-RESPONSES ; AMYLOID-BETA DEPOSITION ; CENTRAL-NERVOUS-SYSTEM ; MOTOR-NEURON DISEASE ; VERSUS-HOST-DISEASE ; BLOOD-BRAIN-BARRIER ; MOUSE MODEL ; ALZHEIMERS-DISEASE |
| 语种 | 英语 |
| WOS记录号 | WOS:000429750000003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/698]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci,Shanghai Ins, 320 Yueyang Rd, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Chen, Xiaodong,Wang, Shijia,Cao, Wei,et al. Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases[J]. CELLULAR IMMUNOLOGY,2018,326(-):8-14. |
| APA | Chen, Xiaodong,Wang, Shijia,Cao, Wei,&,.(2018).Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases.CELLULAR IMMUNOLOGY,326(-),8-14. |
| MLA | Chen, Xiaodong,et al."Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases".CELLULAR IMMUNOLOGY 326.-(2018):8-14. |
入库方式： OAI收割
来源：上海营养与健康研究所
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