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N-6-Methyladenosines Modulate A-to-I RNA Editing

文献类型：期刊论文

作者Xiang, Jian-Feng2,3; Yang, Qin3; Yang, Li1,3; Liu, Chu-Xiao2; Wu, Man2; Chen, Ling-Ling1,2; Wu, Man1; ,
刊名MOLECULAR CELL
出版日期2018
卷号69期号:1页码:126-+
ISSN号1097-2765
DOI10.1016/j.molcel.2017.12.006
文献子类Article
英文摘要N-6-methyladenosine (m(6)A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m(6)A-positive and m(6)A-negative RNA populations. Both the presence and extent of A-to-I sites in m(6)A-negative RNA transcripts suggest a negative correlation between m(6)A and A-to-I. Suppression of m(6)A-catalyzing enzymes results in global A-to-I RNA editing changes. Further depletion of m(6)A modification increases the association of m(6)A-depleted transcripts with adenosine deaminase acting on RNA (ADAR) enzymes, resulting in upregulated A-to-I editing on the same m(6)A-depleted transcripts. Collectively, the effect of m(6)A on A-to-I suggests a previously underappreciated interplay between two distinct and abundant RNA modifications, highlighting a complex epitranscriptomic landscape.
学科主题Biochemistry & Molecular Biology ; Cell Biology
WOS关键词THROUGHPUT SEQUENCING DATA ; GENE-EXPRESSION REGULATION ; MESSENGER-RNA ; LANDSCAPE ; CELLS ; EPITRANSCRIPTOME ; TRANSLATION ; METHYLATION ; NETWORKS ; REVEALS
语种英语
出版者CELL PRESS
WOS记录号WOS:000419255100013
版本出版稿
源URL[http://202.127.25.144/handle/331004/700]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China,
2.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
3.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Xiang, Jian-Feng,Yang, Qin,Yang, Li,et al. N-6-Methyladenosines Modulate A-to-I RNA Editing[J]. MOLECULAR CELL,2018,69(1):126-+.
APA Xiang, Jian-Feng.,Yang, Qin.,Yang, Li.,Liu, Chu-Xiao.,Wu, Man.,...&,.(2018).N-6-Methyladenosines Modulate A-to-I RNA Editing.MOLECULAR CELL,69(1),126-+.
MLA Xiang, Jian-Feng,et al."N-6-Methyladenosines Modulate A-to-I RNA Editing".MOLECULAR CELL 69.1(2018):126-+.

入库方式： OAI收割

来源：上海营养与健康研究所

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