PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21
文献类型：期刊论文
| 作者 | Liu, Xiaoye8,9,10; Zhang, Feifei8; Zhang, Yaping8; Chen, Chiqi8; Zhou, Meiyi8; Yu, Zhuo8; Liu, Yunxia8; Hao, Xiaoxin8; Liu, Ligen8; Xie, Li8 |
| 刊名 | CELL REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 23期号:5页码:1461-1475 |
| 关键词 | ancestral reconstruction copper odorant receptors orthologs sulfur |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2018.03.140 |
| 文献子类 | Article |
| 英文摘要 | In addition to acting as building blocks for biosynthesis, aminoacidsmight serve as signalingregulators in various physiological and pathological processes. However, it remains unknown whether amino acid levels affect the activities of hematopoietic stem cells (HSCs). By using a genetically encoded fluorescent sensor of the intracellular levels of branched-chain amino acids (BCAAs), we couldmonitor the dynamics of BCAA metabolism in HSCs. A mitochondrial-targeted 2C-type Ser/Thr protein phosphatase (PPM1K) promotes the catabolism of BCAAs to maintain MEIS1 and p21 levels by decreasing the ubiquitination-mediated degradation controlled by the E3 ubiquitin ligase CDC20. PPM1K deficiency led to a notable decrease in MEIS1/p21 signaling to reduce the glycolysis and quiescence of HSCs, followed by a severe impairment in repopulation activities. Moreover, the deletion of Ppm1k dramatically extended survival in amurine leukemia model. These findings will enhance the current understanding of nutrient signaling in metabolism and function of stem cells. |
| 学科主题 | Cell Biology |
| WOS关键词 | PROTEIN PHOSPHATASE 2CM ; AMINO-ACID CATABOLISM ; SYRUP-URINE-DISEASE ; STEM-CELLS ; METABOLIC-REGULATION ; HYPOXIC-NICHE ; MITOCHONDRIAL METABOLISM ; INSULIN-RESISTANCE ; SKELETAL-MUSCLE ; LEUCINE |
| 语种 | 英语 |
| WOS记录号 | WOS:000432454500018 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/704]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Ophthalmol, Shanghai, Peoples R China; 2.Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai, Peoples R China; 3.East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Synthet Biol & Biotechnol Lab, Shanghai 200237, Peoples R China; 4.Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol, Shanghai 200025, Peoples R China; 5.Shanghai Jiao Tong Univ, Affiliated People Hosp 6, Ctr Reprod Med, Shanghai 200233, Peoples R China; 6.UT Southwestern Med Ctr, Dept Physiol, Dallas, TX 75390 USA, 7.Binzhou Med Univ, Taishan Immunol Program, Yantai 264003, Peoples R China; 8.Shanghai Jiao Tong Univ, Sch Med,Dept Pathophysiol, Shanghai Tongren Hosp,Key Lab Cell Differentiat &, Minist Educ,Fac Basic Med,Hongqiao Int Inst Med, Shanghai 200025, Peoples R China; 9.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200031, Peoples R China; 10.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Xiaoye,Zhang, Feifei,Zhang, Yaping,et al. PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21[J]. CELL REPORTS,2018,23(5):1461-1475. |
| APA | Liu, Xiaoye.,Zhang, Feifei.,Zhang, Yaping.,Chen, Chiqi.,Zhou, Meiyi.,...&,.(2018).PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.CELL REPORTS,23(5),1461-1475. |
| MLA | Liu, Xiaoye,et al."PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21".CELL REPORTS 23.5(2018):1461-1475. |
入库方式： OAI收割
来源：上海营养与健康研究所
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