Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice
文献类型：期刊论文
| 作者 | Xie, Yinghui; Yuan, Tanglong; Qin, Yanqing; Weng, Zhonghui; Fang, Jing; , |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2018 |
| 卷号 | 50期号:6页码:540-546 |
| 关键词 | prolyl hydroxylase intestinal epithelium homeostasis |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmy037 |
| 文献子类 | Article |
| 英文摘要 | Prolyl hydroxylases (PHD1-3) hydroxylate hypoxia inducible factor alpha (HIF alpha), leading to HIF alpha ubiquitination and degradation. Recent studies indicated that administration of generic inhibitors of PHDs improved mice colitis, suggesting that suppression of PHD activity by these inhibitors may be a potential strategy for the treatment of inflammatory bowel diseases. However, the exact role of each member of PHD family in homeostasis of intestinal epithelium remains elusive. The aim of this work is to study the possible role of PHD2 by using mice with genetic ablation of Phd2 in intestinal epithelial cells (IECs). We found that deletion of PHD2 in IECs did not lead to spontaneous enteritis or colitis in mice. Deletion of PHD2 in IECs did not confer upon mice higher susceptibility to dextran sodium sulfate-induced colitis. Furthermore, in a colitis-associated colon cancer model, the PHD2-conditional knockout mice had similar susceptibility to azoxymethane (AOM)-induced colonic tumorigenesis as control mice did. Our results suggest that PHD2 is dispensable for maintenance of intestinal epithelium homeostasis in mice. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| WOS关键词 | HYPOXIA-INDUCIBLE-FACTOR ; DEXTRAN SODIUM-SULFATE ; BARRIER FUNCTION ; CANCER CELLS ; HIF-ALPHA ; COLITIS ; AZOXYMETHANE ; HIF-1-ALPHA ; INHIBITION ; APOPTOSIS |
| 语种 | 英语 |
| WOS记录号 | WOS:000434861200003 |
| 出版者 | OXFORD UNIV PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/706]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Lab Food Safety Res, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xie, Yinghui,Yuan, Tanglong,Qin, Yanqing,et al. Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50(6):540-546. |
| APA | Xie, Yinghui,Yuan, Tanglong,Qin, Yanqing,Weng, Zhonghui,Fang, Jing,&,.(2018).Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50(6),540-546. |
| MLA | Xie, Yinghui,et al."Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50.6(2018):540-546. |
入库方式： OAI收割
来源：上海营养与健康研究所
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