Non-coding RNAs as biomarkers for acute myocardial infarction
文献类型：期刊论文
| 作者 | Wang, Chen1,2; Jing, Qing1,2; Jing, Qing3; , |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2018 |
| 卷号 | 39期号:7页码:1110-1119 |
| 关键词 | acute myocardial infarction biomarkers non-coding RNAs circulating RNA cardiovascular diseases diagnosis prognosis |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.205 |
| 文献子类 | Review |
| 英文摘要 | Acute myocardial infarction (AMI) is a main threat to human lives worldwide. Early and accurate diagnoses warrant immediate medical care, which would reduce mortality and improve prognoses. Circulating non-coding RNAs have been demonstrated to serve as competent biomarkers for various diseases. Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction. Here, we summarized recent findings on non-coding RNAs as biomarkers for early diagnosis of ST-segment elevation myocardial infarction and for disease monitoring of myocardial infarction. In addition, the prognostic potential of non-coding RNAs in patients treated with percutaneous coronary intervention was also described. We also include studies based on biobanks, and build a miRNA release spectrum after AMI, which provides quantitative and time-lapse monitoring of AMI progress. With this spectrum, we are able to customize personal medical care, which prevents further damage. By constructing a network of circulating non-coding RNAs with high specificity and sensitivity, detailed diagnostic information was provided for personalized medicine. Unveiling the roles and kinetics of circulating non-coding RNAs may lead to a revolution in clinical diagnosis. |
| 学科主题 | Chemistry ; Pharmacology & Pharmacy |
| WOS关键词 | CIRCULATING MICRORNAS ; CARDIOVASCULAR-DISEASE ; CARDIAC-HYPERTROPHY ; EARLY-DIAGNOSIS ; POTENTIAL BIOMARKER ; CLINICAL IMPACT ; HEART-FAILURE ; EARLY PHASE ; PLASMA ; TROPONIN |
| 语种 | 英语 |
| WOS记录号 | WOS:000438943200006 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/707]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China; 3.Changhai Hosp, Dept Cardiol, Shanghai 200433, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Wang, Chen,Jing, Qing,Jing, Qing,et al. Non-coding RNAs as biomarkers for acute myocardial infarction[J]. ACTA PHARMACOLOGICA SINICA,2018,39(7):1110-1119. |
| APA | Wang, Chen,Jing, Qing,Jing, Qing,&,.(2018).Non-coding RNAs as biomarkers for acute myocardial infarction.ACTA PHARMACOLOGICA SINICA,39(7),1110-1119. |
| MLA | Wang, Chen,et al."Non-coding RNAs as biomarkers for acute myocardial infarction".ACTA PHARMACOLOGICA SINICA 39.7(2018):1110-1119. |
入库方式： OAI收割
来源：上海营养与健康研究所
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