Rabbit models provide insights into bone formation related biological process in atherosclerotic vascular calcification
文献类型：期刊论文
| 作者 | Tan, Linuo3; Li, Yixue1,3; Wang, Zhen1; Li, Yixue2,4; , |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 496期号:4页码:1369-1375 |
| 关键词 | Vascular calcification Atherosclerosis Bone formation Osteoclast WHHL |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2018.02.035 |
| 文献子类 | Article |
| 英文摘要 | Featured as ectopic mineralization along blood vessels, vascular calcification is a major risk factor for a number of prevalent diseases including atherosclerosis. As recent studies identify vascular calcification as a tightly regulated process recapitulating embryonic bone formation, in this study, RNA-seq data generated from rabbit models with inherited or induced hyperlipidemia and atherosclerosis were used, to investigate bone formation related signals and biological processes in atherosclerotic vascular calcification. Evident activation of bone formation was found, together with presence and functioning of bone resorption cell osteoclasts, which were found to possibly also promote bone formation in this disease. Resistance of bone formation and calcification were also found, through down-regulation of pro ossification regulators and up-regulation of protective inhibitors and Wnt antagonists. Levels of activation and resistance of bone formation differed between the two disease models, suggesting different underlying mechanisms and corresponding treatments. In addition, loss-of-function of protective inhibitors KL and SOST, and possibly crucial role of GPNMB were also highlighted for treatment or further study. (C) 2018 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| WOS关键词 | SKELETAL DEVELOPMENT ; DISEASE ; MECHANISMS ; EXPRESSION ; UPDATE |
| 语种 | 英语 |
| WOS记录号 | WOS:000426336400054 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/708]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China; 2.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China, 3.Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Dept Bioinformat & Biostat, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; 4.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Tan, Linuo,Li, Yixue,Wang, Zhen,et al. Rabbit models provide insights into bone formation related biological process in atherosclerotic vascular calcification[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,496(4):1369-1375. |
| APA | Tan, Linuo,Li, Yixue,Wang, Zhen,Li, Yixue,&,.(2018).Rabbit models provide insights into bone formation related biological process in atherosclerotic vascular calcification.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,496(4),1369-1375. |
| MLA | Tan, Linuo,et al."Rabbit models provide insights into bone formation related biological process in atherosclerotic vascular calcification".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 496.4(2018):1369-1375. |
入库方式： OAI收割
来源：上海营养与健康研究所
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