中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海营养与健康研究所
  3. 中国科学院上海生命科学研究院营养科学研究所
Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters

文献类型：期刊论文

作者Sun, Hongduo6,7; Gong, Zhaohui7; Yao, Jiaying6,7; Wang, Yuangao7; Shao, Zhen7; Wang, Jiawei5; Zhang, Yijing5; Xu, Jian4; Yuan, Guo-cheng1,2,3; ,
刊名CELL DISCOVERY
出版日期2018
卷号4期号:-页码:38
ISSN号2056-5968
DOI10.1038/s41421-018-0045-y
文献子类Letter
英文摘要[F-18]Fluorodeoxyglucose-PET/CT ((18) F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as F-18-FDG through PET/CT or [I-123/125]b- methyl-p-iodophenyl-pentadecanoic acid with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analyses validate these regions as bona fide fat pads. Our findings indicate that fat depots of rodents show a high degree of topological similarity to those of humans. Studies involving both glucose and lipid tracers indicate differential preferences for these substrates in different depots and also suggest that fatty acid-based visualized approaches may reveal additional brown adipose tissue and beige depots in humans.
学科主题Cell Biology
WOS关键词EXPRESSION ; ENHANCERS
语种英语
WOS记录号WOS:000437846600001
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/712]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Harvard TH Chan Sch Publ Hlth, Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA;
2.Harvard Stem Cell Inst, Cambridge, MA 02138 USA,
3.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA;
4.Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Res Inst, Childrens Med Ctr, Dallas, TX 75390 USA;
5.Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, Shanghai Inst Biol Sci, Natl Key Lab Plant Mol Genet,CAS Ctr Excellence M, Shanghai 200032, Peoples R China;
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
7.Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Sun, Hongduo,Gong, Zhaohui,Yao, Jiaying,et al. Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters[J]. CELL DISCOVERY,2018,4(-):38.
APA Sun, Hongduo.,Gong, Zhaohui.,Yao, Jiaying.,Wang, Yuangao.,Shao, Zhen.,...&,.(2018).Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters.CELL DISCOVERY,4(-),38.
MLA Sun, Hongduo,et al."Quantitative integration of epigenomic variation and transcription factor binding using MAmotif toolkit identifies an important role of IRF2 as transcription activator at gene promoters".CELL DISCOVERY 4.-(2018):38.

入库方式： OAI收割

来源：上海营养与健康研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。