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Rapid and sensitive determination of formamidines and metabolites with HPLC-MS/MS using core-shell columns

文献类型：期刊论文

作者Wu, Yuhong4; Bu, Juan4; Guo, Hao2; Tan, Yanglan5; Zhong, Jian1; Zhao, Qingbiao3; ,
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
出版日期2018
卷号1076期号:-页码:22-28
关键词Formamidines Liquid chromatography tandem-mass spectrometry Core-shell column Blood samples Dispersive liquid-liquid microextraction Response surface methodology
ISSN号1570-0232
DOI10.1016/j.jchromb.2018.01.012
文献子类Article
英文摘要A number of poisoning and suicide cases involving formamidine pesticides have been reported, thus developing a rapid and low cost determination method is crucial. In this work, a rapid, sensitive and low-cost method for the simultaneous determination of formamidine pesticides (amitraz, chlordimeform, formetanate) and their main metabolites, N-(2,4-dimethylphenyl)-N-methyl-formamidine, 2,4-dimethylformamidine, 2,4-dimethylaniline, 4-chloro-2-methylaniline and 3-hydroxyacetanilide in human blood by high-performance liquid chromatography with tandem mass spectrometry is developed. The application of columns with core-shell particles significantly reduced the analysis time. Very low LODs (0.01-0.04 mu g L-1) were obtained for formamidine pesticides and their metabolites. The method was successfully applied to the analysis of human blood samples from a real forensic case. The significantly reduced analysis time, high sensitivity and low cost are the primary advantages of the developed method. This methodology provides important value for sensitive and rapid determination of residue pesticides and metabolites, study of residue pesticides behavior in human body, as well as application in real forensic cases.
学科主题Biochemistry & Molecular Biology ; Chemistry
WOS关键词LIQUID-LIQUID MICROEXTRACTION ; CHROMATOGRAPHY-MASS SPECTROMETRY ; GAS CHROMATOGRAPHY ; HUMAN URINE ; TRANSFORMATION PRODUCTS ; AMITRAZ ; EXTRACTION ; WATER ; PESTICIDES ; PARTICLES
语种英语
WOS记录号WOS:000425555300004
出版者ELSEVIER SCIENCE BV
版本出版稿
源URL[http://202.127.25.144/handle/331004/713]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Shanghai Ocean Univ, Lab Qual & Safety Risk Assessment Aquat Prod Stor, Shanghai Engn Res Ctr Aquat Prod Proc & Preservat, Minist Agr,Coll Food Sci & Technol, Shanghai 201306, Peoples R China;
2.Chongqing Inst Forens Sci, Chongqing 400021, Peoples R China;
3.East China Normal Univ, Dept Elect Engn, Minist Educ, Key Lab Polar Mat & Devices, Shanghai 200241, Peoples R China,
4.Chongqing Police Coll, Dept Forens Sci & Technol, Chongqing 401331, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Wu, Yuhong,Bu, Juan,Guo, Hao,et al. Rapid and sensitive determination of formamidines and metabolites with HPLC-MS/MS using core-shell columns[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2018,1076(-):22-28.
APA Wu, Yuhong.,Bu, Juan.,Guo, Hao.,Tan, Yanglan.,Zhong, Jian.,...&,.(2018).Rapid and sensitive determination of formamidines and metabolites with HPLC-MS/MS using core-shell columns.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1076(-),22-28.
MLA Wu, Yuhong,et al."Rapid and sensitive determination of formamidines and metabolites with HPLC-MS/MS using core-shell columns".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1076.-(2018):22-28.

入库方式： OAI收割

来源：上海营养与健康研究所

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