Peroxisome Proliferator-Activated Receptor gamma and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization
文献类型：期刊论文
| 作者 | Wang, Qiong A.3,4; Zhang, Fang4; Ye, Risheng4; An, Yu4; Shao, Mengle4; Tao, Caroline4; Gupta, Rana K.4; Scherer, Philipp E.4; Jiang, Lei3; Scherer, Philipp E.2 |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 38期号:10页码:UNSP e00677 |
| 关键词 | C/EBP alpha insulin sensitization PPAR gamma thiazolidinedione adipocyte adipose tissue inducible knockout mouse model obesity |
| ISSN号 | 0270-7306 |
| DOI | 10.1128/MCB.00677-17 |
| 文献子类 | Article |
| 英文摘要 | Adipose tissue is a dynamic organ that makes critical contributions to whole-body metabolic homeostasis. Although recent studies have revealed that different fat depots have distinct molecular signatures, metabolic functions and adipogenic mechanisms, peroxisome proliferator-activated receptor gamma(PPAR gamma) is still widely viewed as the master regulator of adipogenesis and critical for maintaining mature adipocyte function. Using an inducible, adipocyte-specific knockout system, we explored the role of PPAR gamma in mature adipocytes in vivo. Short-term PPAR gamma deficiency in adipocytes reduces whole-body insulin sensitivity, but adipocytes are viable both in vitro and in vivo. However, after exposure to a high-fat diet, even short-term PPAR gamma deficiency leads to rapid adipocyte death. When mature adipocytes are depleted of both PPAR gamma and CCAAT-enhancer-binding protein gamma(C/EBP gamma), they are rapidly depleted of lipids and undergo adipocyte death, both in vitro and in vivo. Surprisingly, although thiazolidinediones (TZDs; PPAR gamma agonists) are thought to act mainly on PPAR gamma, PPAR gamma in adipocytes is not required for the whole-body insulin-sensitizing effect of TZDs. This offers new mechanistic aspects of PPAR gamma/TZD action and its effect on whole-body metabolic homeostasis. |
| 学科主题 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS关键词 | PPAR-GAMMA ; ADIPOSE-TISSUE ; HEPATIC STEATOSIS ; IN-VIVO ; FAT ; MICE ; RESISTANCE ; DELETION ; MUSCLE ; MOUSE |
| 语种 | 英语 |
| WOS记录号 | WOS:000431212400009 |
| 出版者 | AMER SOC MICROBIOLOGY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/716]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China, 2.Univ Texas Southwestern Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA; 3.City Hope Beckman Res Inst, Diabet & Metab Res Inst, Det Mol & Cellular Endocrinol, Duarte, CA USA; 4.Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA; |
| 推荐引用方式 GB/T 7714 | Wang, Qiong A.,Zhang, Fang,Ye, Risheng,et al. Peroxisome Proliferator-Activated Receptor gamma and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization[J]. MOLECULAR AND CELLULAR BIOLOGY,2018,38(10):UNSP e00677. |
| APA | Wang, Qiong A..,Zhang, Fang.,Ye, Risheng.,An, Yu.,Shao, Mengle.,...&,.(2018).Peroxisome Proliferator-Activated Receptor gamma and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization.MOLECULAR AND CELLULAR BIOLOGY,38(10),UNSP e00677. |
| MLA | Wang, Qiong A.,et al."Peroxisome Proliferator-Activated Receptor gamma and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization".MOLECULAR AND CELLULAR BIOLOGY 38.10(2018):UNSP e00677. |
入库方式： OAI收割
来源：上海营养与健康研究所
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