Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation
文献类型：期刊论文
| 作者 | Wang, Qiong A.2,3; Zhang, Fang2; Vishvanath, Lavanya2; Ye, Risheng2; Shao, Mengle2; Tao, Caroline2; Gupta, Rana K.2; Scherer, Philipp E.2; Song, Anying3; Jiang, Lei3 |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2018 |
| 卷号 | 28期号:2页码:282-+ |
| 关键词 | Preclinical models Combination therapy Experimental therapeutics Kaempferol Immunotherapy |
| ISSN号 | 1550-4131 |
| DOI | 10.1016/j.cmet.2018.05.022 |
| 文献子类 | Article |
| 英文摘要 | Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfr alpha(+) preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting. |
| 学科主题 | Cell Biology ; Endocrinology & Metabolism |
| WOS关键词 | MAMMARY-GLAND INVOLUTION ; STEM-CELLS ; IN-VIVO ; MORPHOGENESIS ; EXPRESSION ; STAGE |
| 语种 | 英语 |
| WOS记录号 | WOS:000440983900012 |
| 出版者 | CELL PRESS |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/719]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China, 2.Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; 3.City Hope Beckman Res Inst, Diabet & Metab Res Inst, Dept Mol & Cellular Endocrinol, 1500 East Duarte Rd, Duarte, CA 91010 USA; 4.Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Syst Biol & Genet, Lausanne, Switzerland; 5.Swiss Inst Bioinformat, Lausanne, Switzerland; |
| 推荐引用方式 GB/T 7714 | Wang, Qiong A.,Zhang, Fang,Vishvanath, Lavanya,et al. Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation[J]. CELL METABOLISM,2018,28(2):282-+. |
| APA | Wang, Qiong A..,Zhang, Fang.,Vishvanath, Lavanya.,Ye, Risheng.,Shao, Mengle.,...&,.(2018).Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation.CELL METABOLISM,28(2),282-+. |
| MLA | Wang, Qiong A.,et al."Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation".CELL METABOLISM 28.2(2018):282-+. |
入库方式： OAI收割
来源：上海营养与健康研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。