RING tetramerization is required for nuclear body biogenesis and PML sumoylation
文献类型：期刊论文
| 作者 | Wang, Pengran1,2,9; Wu, Haiyan2; Zhen, Tao2; Li, Yuwen2; Chen, Sai-Juan2,4,5,6,8; Chen, Zhu2,4,5,6,8; Meng, Guoyu2,4,5; Benhenda, Shirine4,5,8; Lallemand-Breitenbach, Valerie4,5,8; Jollivet, Florence4,5,8 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:-页码:1277 |
| 关键词 | Cross-Value Association Analysis normalization-free pan-cancer transcriptome heterogeneity |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-03498-0 |
| 文献子类 | Article |
| 英文摘要 | ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the SUMO E2 enzyme. Here, using X-ray crystallography and SAXS characterization, we demonstrate that PML RING tetramerizes through highly conserved PML-specific sequences, which are required for NB assembly and PML sumoylation. Conserved residues implicated in RING dimerization of other TRIMs also contribute to PML tetramer stability. Wild-type PML rescues the ability of some RING mutants to form NBs as well as their sumoylation. Impaired RING tetramerization abolishes PML/RARA-driven leukemogenesis in vivo and arsenic-induced differentiation ex vivo. Our studies thus identify RING tetramerization as a key step in the NB macro-molecular scaffolding. They suggest that higher order RING interactions allow efficient UBC9 recruitment and thus change the biochemical nature of TRIM-facilitated post-translational modifications. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | ACUTE PROMYELOCYTIC LEUKEMIA ; CATALYTIC ACTIVATION ; STRUCTURE REFINEMENT ; OXIDATIVE STRESS ; FINGER DOMAIN ; PROTEIN PML ; BODIES ; ONCOPROTEIN ; CURE ; POLYUBIQUITIN |
| 语种 | 英语 |
| WOS记录号 | WOS:000428621300001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/721]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China; 2.Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai Inst Hematol, State Key Lab Med Genom,Sch Med, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China; 3.Hop St Louis, AP HP, Serv Biochim, F-75475 Paris, France, 4.INSERM, RuiJin Hosp, Lab Int Associe Hematol & Canc, Shanghai, Peoples R China; 5.CNRS, Shanghai, Peoples R China; 6.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China; 7.Paris Sci Lettres Res Univ, Coll France, 11 Pl Marcelin Berthelot, F-75005 Paris, France; 8.Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis 1, INSERM,CNRS,Equipe Labellisee LNCC,U944,UMR7212, F-75475 Paris, France; 9.Chinese Acad Sci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Pengran,Wu, Haiyan,Zhen, Tao,et al. RING tetramerization is required for nuclear body biogenesis and PML sumoylation[J]. NATURE COMMUNICATIONS,2018,9(-):1277. |
| APA | Wang, Pengran.,Wu, Haiyan.,Zhen, Tao.,Li, Yuwen.,Chen, Sai-Juan.,...&,.(2018).RING tetramerization is required for nuclear body biogenesis and PML sumoylation.NATURE COMMUNICATIONS,9(-),1277. |
| MLA | Wang, Pengran,et al."RING tetramerization is required for nuclear body biogenesis and PML sumoylation".NATURE COMMUNICATIONS 9.-(2018):1277. |
入库方式： OAI收割
来源：上海营养与健康研究所
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