Roadmap for investigating epigenome deregulation and environmental origins of cancer
文献类型：期刊论文
| 作者 | Herceg, Zdenko2; Ghantous, Akram2; Wild, Christopher P.2; Sklias, Athena2; Ambatipudi, Srikant2; Degli Esposti, Davide2; Hernandez-Vargas, Hector2; Casati, Lavinia3; Duthie, Susan J.4; Fry, Rebecca5 |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2018 |
| 卷号 | 142期号:5页码:874-882 |
| 关键词 | epigenetics environment cancer molecular mechanisms research gaps perspectives biomarkers |
| ISSN号 | 0020-7136 |
| DOI | 10.1002/ijc.31014 |
| 文献子类 | Review |
| 英文摘要 | The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific (fingerprints) that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment. |
| 学科主题 | Oncology |
| WOS关键词 | DNA METHYLATION DATA ; EPIGENETIC EPIDEMIOLOGY ; MATERNAL SMOKING ; CELL-TYPES ; GENOME ; MECHANISMS ; IDENTIFICATION ; CHALLENGES ; PREVENTION ; REGULATORS |
| 语种 | 英语 |
| WOS记录号 | WOS:000419362200001 |
| 出版者 | WILEY |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/722]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Baylor Coll Med, Texas Childrens Hosp, Houston, TX 77030 USA; 2.Int Agcy Res Canc, 150 Cours Albert Thomas, F-69008 Lyon, France; 3.Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy; 4.Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen, Scotland; 5.UNC, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA; 6.Fels Inst Canc Res Mol Biol, Philadelphia, PA USA; 7.Univ Arkansas Med Sci, Little Rock, AR 72205 USA; 8.Aichi Canc Ctr Res Inst, Nagoya, Aichi, Japan; 9.INSERM, Albert Bonniot Inst, Grenoble, France; 10.Natl Canc Inst INCA, Rio De Janeiro, Brazil; |
| 推荐引用方式 GB/T 7714 | Herceg, Zdenko,Ghantous, Akram,Wild, Christopher P.,et al. Roadmap for investigating epigenome deregulation and environmental origins of cancer[J]. INTERNATIONAL JOURNAL OF CANCER,2018,142(5):874-882. |
| APA | Herceg, Zdenko.,Ghantous, Akram.,Wild, Christopher P..,Sklias, Athena.,Ambatipudi, Srikant.,...&,.(2018).Roadmap for investigating epigenome deregulation and environmental origins of cancer.INTERNATIONAL JOURNAL OF CANCER,142(5),874-882. |
| MLA | Herceg, Zdenko,et al."Roadmap for investigating epigenome deregulation and environmental origins of cancer".INTERNATIONAL JOURNAL OF CANCER 142.5(2018):874-882. |
入库方式： OAI收割
来源：上海营养与健康研究所
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