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RING tetramerization is required for nuclear body biogenesis and PML sumoylation (vol 9, 1277, 2018)

文献类型：期刊论文

作者Wang, Pengran2,3,4; Wu, Haiyan2; Zhen, Tao2; Li, Yuwen2; Chen, Sai-Juan2,3,4,6,7,8; Chen, Zhu2,3,4,6,7,8; Meng, Guoyu2,6,7; Benhenda, Shirine5,6,7; Lallemand-Breitenbach, Valerie5,6,7; Jollivet, Florence5,6,7
刊名NATURE COMMUNICATIONS
出版日期2018
卷号9期号:-页码:1841
关键词cholecalciferol bone turnover markers randomized placebo-controlled trial
ISSN号2041-1723
DOI10.1038/s41467-018-04347-w
文献子类Correction
英文摘要Background: Bone turnover markers (BTMs) are proposed as alternative indicators for bone mineral density in diagnosis and management of osteoporosis. However, little is known about the effects of vitamin D supplementation on BTMs in nonwhite populations. Objective: We aimed to investigate the responses in BTMs after vitamin D supplementation in Asians. Methods: In this secondary data analysis of a randomized, double-blind, placebo-controlled trial, 448 Chinese adults [mean +/- SD age: 31.9 +/- 8.0 y; mean +/- SD body mass index (kg/m(2)): 22.1 +/- 2.6; 69% were women] with vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] <50 nmol/L) received 2000 IU/d cholecalciferol or placebo for 20 wk. Serum concentrations of 25(OH)D, parathyroid hormone (PTH), calcium, and markers of bone formation and resorption were measured at weeks 0 and 20. Intention-to-treat analysis was applied, and between-group differences were compared by general linear models with adjustments. Results: Cholecalciferol supplementation increased the serum bone alkaline phosphatase (BALP) concentration (+1.7 +/- 1.9 mu g/L) significantly more than placebo (+1.1 +/- 1.7 mu g/L; P= 0.004), but not circulating concentrations of procollagen type I N-terminal propeptide (PINP), beta-isomerized C-terminal telopeptide of type I collagen (beta-CTX), or tartrate-resistant acid phosphatase 5b (TRAP5b) (P >= 0.53). Notably, a pooled analysis indicated that changes in serum 25(OH)D were positively associated with changes in serum BALD PINP and TRAP5b (r = 0.07-0.16, P <= 0.02), but inversely with changes in PTH (r= -0.15, P < 0.001). Among cholecalciferol-treated participants, individuals who achieved serum 25(OH)D >= 75 nmol/L had greater increases in serum beta-CTX (224% compared with 146%; P= 0.02) and TRAP5b (22.2% compared with 9.1%; P = 0.007), but smaller decreases in serum calcium (-1.3% compared with -1.9%; P = 0.005) and calcium-phosphorus product (-2.6% compared with -3.3%; P= 0.02) compared with those with serum 25(OH)D <75 nmol/L. Conclusions: Daily supplementation with 2000 IU cholecalciferol for 20 wk may promote bone formation in Chinese adults with vitamin D deficiency. More studies are needed to elucidate the potential clinical implications of BTMs.
学科主题Science & Technology - Other Topics
语种英语
WOS记录号WOS:000431412500001
出版者NATURE PUBLISHING GROUP
版本出版稿
源URL[http://202.127.25.144/handle/331004/723]  
专题中国科学院上海生命科学研究院营养科学研究所
作者单位1.Hop St Louis, AP HP, Serv Biochim, F-75475 Paris, France,
2.Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai Inst Hematol, State Key Lab Med Genom,Sch Med, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
4.Chinese Acad Sci, Grad Sch, 320 Yueyang Rd, Shanghai 200031, Peoples R China;
5.Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis 1, INSERM,U944,CNRS,UMR7212,Equipe Labellisee LNCC, F-75475 Paris, France;
6.RuiJin Hosp, INSERM, Lab Int Associe Hematol & Canc, Shanghai, Peoples R China;
7.CNRS, Shanghai, Peoples R China;
8.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China;
9.Paris Sci Lettres Res Univ, Coll France, 11 Pl Marcelin Berthelot, F-75005 Paris, France;
推荐引用方式
GB/T 7714		 Wang, Pengran,Wu, Haiyan,Zhen, Tao,et al. RING tetramerization is required for nuclear body biogenesis and PML sumoylation (vol 9, 1277, 2018)[J]. NATURE COMMUNICATIONS,2018,9(-):1841.
APA Wang, Pengran.,Wu, Haiyan.,Zhen, Tao.,Li, Yuwen.,Chen, Sai-Juan.,...&,.(2018).RING tetramerization is required for nuclear body biogenesis and PML sumoylation (vol 9, 1277, 2018).NATURE COMMUNICATIONS,9(-),1841.
MLA Wang, Pengran,et al."RING tetramerization is required for nuclear body biogenesis and PML sumoylation (vol 9, 1277, 2018)".NATURE COMMUNICATIONS 9.-(2018):1841.

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来源：上海营养与健康研究所

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