Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation
文献类型：期刊论文
| 作者 | Cheng, Hao1,4; Xuan, Hongwen1,4; Green, Christopher D.4; Han, Yixing4; Sun, Na4; McDermott, Joseph4; Han, Jing-Dong J.4; Shen, Hongjie2,5,6,7; Lan, Fei2,5,6,7; Bennett, David A.3 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2018 |
| 卷号 | 115期号:29页码:7611-7616 |
| 关键词 | inflammation aging brain H3K27ac gene-body acetylation |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.1800656115 |
| 文献子类 | Article |
| 英文摘要 | Brain "inflammaging," a low-grade and chronic inflammation, is a major hallmark for aging-related neurodegenerative diseases. Here, by profiling H3K27ac and gene expression patterns in human and mouse brains, we found that age-related up-regulated (Age-Up) and down-regulated (Age-Down) genes have distinct H3K27ac patterns. Although both groups show promoter H3K27ac, the Age-Up genes, enriched for inflammation-related functions, are additionally marked by broad H3K27ac distribution over their gene bodies, which is progressively reduced during aging. Age-related gene expression changes can be predicted by gene-body H3K27ac level. Contrary to the presumed transcription activation function of promoter H3K27ac, we found that broad gene-body hyper H3K27ac suppresses overexpression of inflammaging genes. Altogether, our findings revealed opposite regulations by H3K27ac of Age-Up and Age-Down genes and a mode of broad gene-body H3K27ac in repressing transcription. |
| 学科主题 | Science & Technology - Other Topics |
| WOS关键词 | NF-KAPPA-B ; ELEGANS LIFE-SPAN ; C. ELEGANS ; DEPENDENT MANNER ; SUPER-ENHANCERS ; EXPRESSION ; DEACETYLATION ; INHIBITION ; ELONGATION ; GENOME |
| 语种 | 英语 |
| WOS记录号 | WOS:000438892600068 |
| 出版者 | NATL ACAD SCIENCES |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/724]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 2.Fudan Univ, Minist Sci & Technol, Key Lab Epigenet & Metab, Shanghai 200032, Peoples R China; 3.Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA, 4.Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev Biol, Max Planck Partner Inst Computat Biol,Key Lab Com, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China; 5.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Shanghai 200032, Peoples R China; 6.Fudan Univ, Minist Educ, Key Lab Carcinogenesis & Canc Invas, Shanghai 200032, Peoples R China; 7.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Cheng, Hao,Xuan, Hongwen,Green, Christopher D.,et al. Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2018,115(29):7611-7616. |
| APA | Cheng, Hao.,Xuan, Hongwen.,Green, Christopher D..,Han, Yixing.,Sun, Na.,...&,.(2018).Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,115(29),7611-7616. |
| MLA | Cheng, Hao,et al."Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 115.29(2018):7611-7616. |
入库方式： OAI收割
来源：上海营养与健康研究所
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