Statistical and integrative system-level analysis of DNA methylation data
文献类型：期刊论文
| 作者 | Teschendorff, Andrew E.1,3,4; Relton, Caroline L.2; , |
| 刊名 | NATURE REVIEWS GENETICS
 |
| 出版日期 | 2018 |
| 卷号 | 19期号:3页码:129-147 |
| 关键词 | all-trans retinoic acid acute promyelocytic leukemia neutrophil G0 G1 switch gene 2 |
| ISSN号 | 1471-0056 |
| DOI | 10.1038/nrg.2017.86 |
| 文献子类 | Review |
| 英文摘要 | Epigenetics plays a key role in cellular development and function. Alterations to the epigenome are thought to capture and mediate the effects of genetic and environmental risk factors on complex disease. Currently, DNA methylation is the only epigenetic mark that can be measured reliably and genome-wide in large numbers of samples. This Review discusses some of the key statistical challenges and algorithms associated with drawing inferences from DNA methylation data, including cell-type heterogeneity, feature selection, reverse causation and system-level analyses that require integration with other data types such as gene expression, genotype, transcription factor binding and other epigenetic information. |
| 学科主题 | Genetics & Heredity |
| WOS关键词 | EPIGENOME-WIDE ASSOCIATION ; CELL-TYPE HETEROGENEITY ; SURROGATE VARIABLE ANALYSIS ; GENE-EXPRESSION CHANGES ; CANCER GENOMIC DATA ; ALL-CAUSE MORTALITY ; MENDELIAN RANDOMIZATION ; MICROARRAY DATA ; LUNG-CANCER ; CPG SITES |
| 语种 | 英语 |
| WOS记录号 | WOS:000425031400005 |
| 出版者 | NATURE PUBLISHING GROUP |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/728]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.UCL, UCL Canc Inst, 72 Huntley St, London WC1E 6BT, England; 2.Univ Bristol, Sch Social & Community Med, MRC IEU, Oakfield House, Bristol BS8 2BN, Avon, England, 3.UCL, Dept Womens Canc, 74 Huntley St, London WC1E 6AU, England; 4.Chinese Acad Sci, MPG, Partner Inst Computat Biol, Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Teschendorff, Andrew E.,Relton, Caroline L.,,. Statistical and integrative system-level analysis of DNA methylation data[J]. NATURE REVIEWS GENETICS,2018,19(3):129-147. |
| APA | Teschendorff, Andrew E.,Relton, Caroline L.,&,.(2018).Statistical and integrative system-level analysis of DNA methylation data.NATURE REVIEWS GENETICS,19(3),129-147. |
| MLA | Teschendorff, Andrew E.,et al."Statistical and integrative system-level analysis of DNA methylation data".NATURE REVIEWS GENETICS 19.3(2018):129-147. |
入库方式： OAI收割
来源：上海营养与健康研究所
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