SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
文献类型：期刊论文
| 作者 | Xu, Zhejun2; Liang, Qifei2; Song, Xiaolei2; Zhang, Zhuangzhi2; Li, Zhenmeiyu2; Wen, Yan2; Liu, Guoping2; Guo, Teng2; Qi, Dashi2; Wang, Min2 |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2018 |
| 卷号 | 145期号:14页码:UNSP dev165456 |
| ISSN号 | 0950-1991 |
| 关键词 | Sp8 Sp9 Six3 LGE DRD2 Striatum Medium spiny neuron Mouse |
| DOI | 10.1242/dev.165456 |
| 文献子类 | Article |
| 英文摘要 | Dopamine receptor DRD1-expressing medium spiny neurons (D1 MSNs) and dopamine receptor DRD2-expressing medium spiny neurons (D2 MSNs) are the principal projection neurons in the striatum, which is divided into dorsal striatum (caudate nucleus and putamen) and ventral striatum (nucleus accumbens and olfactory tubercle). Progenitors of these neurons arise in the lateral ganglionic eminence (LGE). Using conditional deletion, we show that mice lacking the transcription factor genes Sp8 and Sp9 lose virtually all D2 MSNs as a result of reduced neurogenesis in the LGE, whereas D1 MSNs are largely unaffected. SP8 and SP9 together drive expression of the transcription factor Six3 in a spatially restricted domain of the LGE subventricular zone. Conditional deletion of Six3 also prevents the formation of most D2 MSNs, phenocopying the Sp8/9 mutants. Finally, ChIP-Seq reveals that SP9 directly binds to the promoter and a putative enhancer of Six3. Thus, this study defines components of a transcription pathway in a regionally restricted LGE progenitor domain that selectively drives the generation of D2 MSNs. |
| 学科主题 | Developmental Biology |
| WOS关键词 | TRANSCRIPTION FACTOR SP8 ; OLFACTORY-BULB NEUROGENESIS ; DEVELOPING MOUSE-BRAIN ; NEOCORTICAL INTERNEURONS ; GANGLIONIC EMINENCE ; PROJECTION NEURONS ; EYE DEVELOPMENT ; CELL-TYPES ; RNA-SEQ ; GENE |
| 语种 | 英语 |
| 出版者 | COMPANY BIOLOGISTS LTD |
| WOS记录号 | WOS:000440421300019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/731]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所 |
| 作者单位 | 1.Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA; 2.Fudan Univ, Zhongshan Hosp, Dept Neurol, State Key Lab Med Neurobiol,Inst Brain Sci, Shanghai 200032, Peoples R China; 3.Univ Calif San Francisco, UCSF Weill Inst Neurosci, Nina Ireland Lab Dev Neurobiol, Dept Psychiat, San Francisco, CA 94158 USA; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, Shanghai 200031, Peoples R China, |
| 推荐引用方式 GB/T 7714 | Xu, Zhejun,Liang, Qifei,Song, Xiaolei,et al. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression[J]. DEVELOPMENT,2018,145(14):UNSP dev165456. |
| APA | Xu, Zhejun.,Liang, Qifei.,Song, Xiaolei.,Zhang, Zhuangzhi.,Li, Zhenmeiyu.,...&,.(2018).SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.DEVELOPMENT,145(14),UNSP dev165456. |
| MLA | Xu, Zhejun,et al."SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression".DEVELOPMENT 145.14(2018):UNSP dev165456. |
入库方式： OAI收割
来源：上海营养与健康研究所
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